抄録
The effects of agents which are known to be differentiation inducers on a human hepatoma cell line PLC/PRF/5 were investigated. Dexamethasone (DEX), sodium butyrate (SB) or dimethylsulfoxide (DMSO) were examined. They all reduced cell proliferation but differ from each other in effect on the secretion of alphafetoprotein (AFP) and hepatitis B surface antigen (HBsAg), changes in morphology and RNA transcription. SB changed the cell from polygonal into a fibroblast-like type and decreased AFP secretion. DMSO decreased the cell size and changed AFP secretion in the same manner as SB. DEX changed the cell into a larger size, as well as increased AFP secretion. HBsAg secretion and also HB virus DNA transcription was enhanced by 3 agents. AFP and myc gene transcriptions were reduced by SB but DMSO reduced only AFP. Albumin gene transcription was enhanced by SB and DEX. These results indicate that the decrease of PLC/PRF/5 proliferation is induced through different mechanisms by these 3 agents.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 75-84 |
| ページ数 | 10 |
| ジャーナル | Cancer biochemistry biophysics |
| 巻 | 13 |
| 号 | 2 |
| 出版ステータス | Published - 1992 11月 |
ASJC Scopus subject areas
- 生物理学
- 癌研究
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
