TY - JOUR
T1 - Effectiveness of trivalent inactivated influenza vaccine in children estimated by a test-negative case-control design study based on influenza rapid diagnostic test results
AU - Shinjoh, Masayoshi
AU - Sugaya, Norio
AU - Yamaguchi, Yoshio
AU - Tomidokoro, Yuka
AU - Sekiguchi, Shinichiro
AU - Mitamura, Keiko
AU - Fujino, Motoko
AU - Shiro, Hiroyuki
AU - Komiyama, Osamu
AU - Taguchi, Nobuhiko
AU - Nakata, Yuji
AU - Yoshida, Naoko
AU - Narabayashi, Atsushi
AU - Myokai, Michiko
AU - Sato, Masanori
AU - Furuichi, Munehiro
AU - Baba, Hiroaki
AU - Fujita, Hisayo
AU - Sato, Akihiro
AU - Ookawara, Ichiro
AU - Tsunematsu, Kenichiro
AU - Yoshida, Makoto
AU - Kono, Mio
AU - Tanaka, Fumie
AU - Kawakami, Chiharu
AU - Kimiya, Takahisa
AU - Takahashi, Takao
AU - Iwata, Satoshi
N1 - Publisher Copyright:
© 2015 Shinjoh et al.
PY - 2015/8/28
Y1 - 2015/8/28
N2 - We assessed vaccine effectiveness (VE) against medically attended, laboratory-confirmed influenza in children 6 months to 15 years of age in 22 hospitals in Japan during the 2013-14 season. Our study was conducted according to a test-negative case-control design based on influenza rapid diagnostic test (IRDT) results. Outpatients who came to our clinics with a fever of 38°C or over and had undergone an IRDT were enrolled in this study. Patients with positive IRDT results were recorded as cases, and patients with negative results were recorded as controls. Between November 2013 and March 2014, a total of 4727 pediatric patients (6 months to 15 years of age) were enrolled: 876 were positive for influenza A, 66 for A(H1N1)pdm09 and in the other 810 the subtype was unknown; 1405 were positive for influenza B; and 2445 were negative for influenza. Overall VE was 46% (95% confidence interval [CI], 39-52). Adjusted VE against influenza A, influenza A(H1N1) pdm09, and influenza B was 63% (95% CI, 56-69), 77% (95% CI, 59-87), and 26% (95% CI, 14-36), respectively. Influenza vaccine was not effective against either influenza A or influenza B in infants 6 to 11 months of age. Two doses of influenza vaccine provided better protection against influenza A infection than a single dose did. VE against hospitalization influenza A infection was 76%. Influenza vaccine was effective against influenza A, especially against influenza A(H1N1)pdm09, but was much less effective against influenza B.
AB - We assessed vaccine effectiveness (VE) against medically attended, laboratory-confirmed influenza in children 6 months to 15 years of age in 22 hospitals in Japan during the 2013-14 season. Our study was conducted according to a test-negative case-control design based on influenza rapid diagnostic test (IRDT) results. Outpatients who came to our clinics with a fever of 38°C or over and had undergone an IRDT were enrolled in this study. Patients with positive IRDT results were recorded as cases, and patients with negative results were recorded as controls. Between November 2013 and March 2014, a total of 4727 pediatric patients (6 months to 15 years of age) were enrolled: 876 were positive for influenza A, 66 for A(H1N1)pdm09 and in the other 810 the subtype was unknown; 1405 were positive for influenza B; and 2445 were negative for influenza. Overall VE was 46% (95% confidence interval [CI], 39-52). Adjusted VE against influenza A, influenza A(H1N1) pdm09, and influenza B was 63% (95% CI, 56-69), 77% (95% CI, 59-87), and 26% (95% CI, 14-36), respectively. Influenza vaccine was not effective against either influenza A or influenza B in infants 6 to 11 months of age. Two doses of influenza vaccine provided better protection against influenza A infection than a single dose did. VE against hospitalization influenza A infection was 76%. Influenza vaccine was effective against influenza A, especially against influenza A(H1N1)pdm09, but was much less effective against influenza B.
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U2 - 10.1371/journal.pone.0136539
DO - 10.1371/journal.pone.0136539
M3 - Article
C2 - 26317334
AN - SCOPUS:84943279620
SN - 1932-6203
VL - 10
JO - PloS one
JF - PloS one
IS - 8
M1 - e0136539
ER -