抄録
To investigate the effects of carteolol hydrochloride on choroidal neovascularization (CNV). Laser photocoagulation was performed to induce CNV in C 57 BL/6 mice. The response of CNV was assessed by fluorescein isothiocyanate-isolectin B 4 staining. The expression of intercellular adhesion molecule (ICAM)-1 and monocyte chemotactic protein (MCP)-1 in the retinal pigment epithelium (RPE)-choroid complex and tumor necrosis factor (TNF)-alpha in the RAW 264.7 macrophage culture was evaluated by enzyme-linked immunosorbent assay. Carteolol hydrochloride application led to significant suppression of the generation of CNV, the production of ICAM-1 and MCP-1 in the RPE-choroid, and macrophage expression of TNF-alpha. Carteolol hydrochloride prevented CNV development through its anti-inflammatory action.
本文言語 | English |
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ページ(範囲) | 355-361 |
ページ数 | 7 |
ジャーナル | Nippon Ganka Gakkai zasshi |
巻 | 115 |
号 | 4 |
出版ステータス | Published - 2011 4月 |
ASJC Scopus subject areas
- 医学一般