TY - CONF
T1 - Effects of graft densities and chain lengths on separation of bioactive compounds on nanolayered thermoresponsive polymer grafted surfaces
AU - Nagase, Kenichi
AU - Kobayashi, Jun
AU - Kikuchi, Akihiko
AU - Kanazawa, Hideko
AU - Okano, Teruo
PY - 2006/10/19
Y1 - 2006/10/19
N2 - We introduced poly(N-isopropylacrylamide) (PIPAAm) brush onto silica bead surfaces with various graft densities and chain lengths by surface-initiated atom transfer radical polymerization (ATRP) technique. Ulitilizing these PIPAAm-grafted beads as chromatographic column matrixes, temperature-dependent elution profiles of steroids were examined at various temperature. Chromatograms with narrow peak widths were obtained by decreasing graft density of PIPAAm. Consequently, the graft density of PIPAAm affects the separation efficiency of PIPAAm grafted columns.
AB - We introduced poly(N-isopropylacrylamide) (PIPAAm) brush onto silica bead surfaces with various graft densities and chain lengths by surface-initiated atom transfer radical polymerization (ATRP) technique. Ulitilizing these PIPAAm-grafted beads as chromatographic column matrixes, temperature-dependent elution profiles of steroids were examined at various temperature. Chromatograms with narrow peak widths were obtained by decreasing graft density of PIPAAm. Consequently, the graft density of PIPAAm affects the separation efficiency of PIPAAm grafted columns.
KW - Bioactive compounds
KW - Chromatography
KW - Graft density
KW - Living radical polymerization
KW - Thermoresponsive surfaces
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M3 - Paper
AN - SCOPUS:33749830946
T2 - 55th SPSJ Annual Meeting
Y2 - 24 May 2006 through 26 May 2006
ER -