Effects of Ligands and Additive Alcohols on Enantioselection in Highly Efficient Asymmetric Borohydride Reduction of Ketones Catalyzed by Optically Active Aldiminato Cobalt(II) Complexes

Takushi Nagata, Kiyoaki D. Sugi, Tohru Yamada, Teruaki Mukaiyama

研究成果: Article査読

34 被引用数 (Scopus)

抄録

Highly enantioselective reduction of ketones with sodium borohydride was achieved in the presence of a catalytic amount of optically active aldiminato cobalt(II) complexes to afford the corresponding secondary alcohols in quantitative yields with high enantiomeric excesses. The effects of ligands of the cobalt(II) complexes and of the additive alcohol pairs used for modification of the borohydride on the present reduction were described. The enantiofacial discrimination in the present asymmetric reduction was discussed based on the conformation of the cobalt complex determined by X-ray analysis.

本文言語English
ページ(範囲)1076-1078
ページ数3
ジャーナルSynlett
1996
11
DOI
出版ステータスPublished - 1996
外部発表はい

ASJC Scopus subject areas

  • 有機化学

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