TY - JOUR
T1 - Effects of omeprazole on gastric mucosal growth and differentiation in developing rat
AU - Kakei, Nobuyuki
AU - Ichinose, Masao
AU - Tsukada, Shinko
AU - Tatematsu, Masae
AU - Tezuka, Noriaki
AU - Furihata, Chie
AU - Yahagi, Naohisa
AU - Matsushima, Masashi
AU - Miki, Kazumasa
AU - Kurokawa, Kiyoshi
AU - Takahashi, Kenji
AU - Yonezawa, Satoshi
AU - Fukamachi, Hiroshi
PY - 1993/11/30
Y1 - 1993/11/30
N2 - The effects of omeprazole on developing rat stomach mucosa were investigated. Infant rats were given subcutaneous injections of either omeprazole (25 mg/kg body weight/day) or vehicle once a day from the day after birth. As a result, omeprazole caused an elevation of mucosal pH and suppressed an increase in mucosal pepsinogen and its mRNA levels during stomach development. Histologically, these changes were associated with a reduction in mature pepsinogen-producing cells throughout stomach mucosa. Omeprazole also caused a delay in the expression of cathepsin E in surface mucous cells and an increase in labeled cells with bromodeoxyuridine. Thus, the present results indicate that omeprazole induces an increase in mucosal cell proliferation and delays the differentiation of developing rat stomach mucosa. Since the observed changes were remarkable especially from days 15 to 21 after birth when significant development of acid secretion occurs, the effects of omeprazole appear to be related with the potent acid inhibitory effect of the reagent.
AB - The effects of omeprazole on developing rat stomach mucosa were investigated. Infant rats were given subcutaneous injections of either omeprazole (25 mg/kg body weight/day) or vehicle once a day from the day after birth. As a result, omeprazole caused an elevation of mucosal pH and suppressed an increase in mucosal pepsinogen and its mRNA levels during stomach development. Histologically, these changes were associated with a reduction in mature pepsinogen-producing cells throughout stomach mucosa. Omeprazole also caused a delay in the expression of cathepsin E in surface mucous cells and an increase in labeled cells with bromodeoxyuridine. Thus, the present results indicate that omeprazole induces an increase in mucosal cell proliferation and delays the differentiation of developing rat stomach mucosa. Since the observed changes were remarkable especially from days 15 to 21 after birth when significant development of acid secretion occurs, the effects of omeprazole appear to be related with the potent acid inhibitory effect of the reagent.
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U2 - 10.1006/bbrc.1993.2477
DO - 10.1006/bbrc.1993.2477
M3 - Article
C2 - 8250940
AN - SCOPUS:0027507536
SN - 0006-291X
VL - 197
SP - 310
EP - 318
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -