Effects of therapeutic ultrasound on the nucleus and genomic DNA

Yukihiro Furusawa, Mariame A. Hassan, Qing Li Zhao, Ryohei Ogawa, Yoshiaki Tabuchi, Takashi Kondo

研究成果: Article査読

32 被引用数 (Scopus)


In recent years, data have been accumulating on the ability of ultrasound to affect at a distance inside the cell. Previous conceptions about therapeutic ultrasound were mainly based on compromising membrane permeability and triggering some biochemical reactions. However, it was shown that ultrasound can access deep to the nuclear territory resulting in enhanced macromolecular localization as well as alterations in gene and protein expression. Recently, we have reported on the occurrence of DNA double-strand breaks in different human cell lines exposed to ultrasound in vitro with some insight into the subsequent DNA damage response and repair pathways. The impact of these observed effects again sways between extremes. It could be advantageous if employed in gene therapy, wound and bone fracture-accelerated healing to promote cellular proliferation, or in cancer eradication if the DNA lesions would culminate in cell death. However, it could be a worrying sign if they were penultimate to further cellular adaptations to stresses and thus shaking the safety of ultrasound application in diagnosis and therapy. In this review, an overview of the rationale of therapeutic ultrasound and the salient knowledge on ultrasound-induced effects on the nucleus and genomic DNA will be presented. The implications of the findings will be discussed hopefully to provide guidance to future ultrasound research.

ジャーナルUltrasonics Sonochemistry
出版ステータスPublished - 2014 11月

ASJC Scopus subject areas

  • 環境化学
  • 化学工学(その他)
  • 放射線学、核医学およびイメージング
  • 音響学および超音波学
  • 有機化学
  • 無機化学


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