Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet's Disease

Takaaki Kawaguchi; Masayuki Fukata; Teppei Omori; Hiroki Kiyohara; Shinya Sugimoto; Kosaku Nanki; Tomohisa Sujino; Yohei Mikami; Takanori Kanai

doi:10.1093/crocol/otac017

Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet's Disease

Takaaki Kawaguchi, Masayuki Fukata, Teppei Omori, Hiroki Kiyohara, Shinya Sugimoto, Kosaku Nanki, Tomohisa Sujino, Yohei Mikami, Takanori Kanai

研究成果: Article › 査読

抄録

Background: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Behçet's disease (intestinal BD) has not been explored. Methods: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was conducted. Results: Of 16 patients, 12 (75%) showed a clinical response and 5 (31.3%) achieved clinical remission after 2 weeks of CNI treatment. Similar efficacy of CNIs was observed even in 7 patients refractory to antitumor necrosis factor-alpha therapies. Endoscopic improvement was observed in 11 of 12 patients. Conclusions: CNIs may be promising treatment options for refractory intestinal BD.

本文言語	English
論文番号	otac017
ジャーナル	Crohn's and Colitis 360
巻	4
号	3
DOI	https://doi.org/10.1093/crocol/otac017
出版ステータス	Published - 2022 7月 1

ASJC Scopus subject areas

消化器病学

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10.1093/crocol/otac017

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title = "Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Beh{\c c}et's Disease",

abstract = "Background: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Beh{\c c}et's disease (intestinal BD) has not been explored. Methods: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was conducted. Results: Of 16 patients, 12 (75%) showed a clinical response and 5 (31.3%) achieved clinical remission after 2 weeks of CNI treatment. Similar efficacy of CNIs was observed even in 7 patients refractory to antitumor necrosis factor-alpha therapies. Endoscopic improvement was observed in 11 of 12 patients. Conclusions: CNIs may be promising treatment options for refractory intestinal BD.",

keywords = "Calcineurin inhibitor, Cyclosporin, Intestinal Beh{\c c}et's disease, Tacrolimus",

author = "Takaaki Kawaguchi and Masayuki Fukata and Teppei Omori and Hiroki Kiyohara and Shinya Sugimoto and Kosaku Nanki and Tomohisa Sujino and Yohei Mikami and Takanori Kanai",

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doi = "10.1093/crocol/otac017",

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T1 - Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet's Disease

AU - Kawaguchi, Takaaki

AU - Fukata, Masayuki

AU - Omori, Teppei

AU - Kiyohara, Hiroki

AU - Sugimoto, Shinya

AU - Nanki, Kosaku

AU - Sujino, Tomohisa

AU - Mikami, Yohei

AU - Kanai, Takanori

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Background: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Behçet's disease (intestinal BD) has not been explored. Methods: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was conducted. Results: Of 16 patients, 12 (75%) showed a clinical response and 5 (31.3%) achieved clinical remission after 2 weeks of CNI treatment. Similar efficacy of CNIs was observed even in 7 patients refractory to antitumor necrosis factor-alpha therapies. Endoscopic improvement was observed in 11 of 12 patients. Conclusions: CNIs may be promising treatment options for refractory intestinal BD.

AB - Background: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Behçet's disease (intestinal BD) has not been explored. Methods: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was conducted. Results: Of 16 patients, 12 (75%) showed a clinical response and 5 (31.3%) achieved clinical remission after 2 weeks of CNI treatment. Similar efficacy of CNIs was observed even in 7 patients refractory to antitumor necrosis factor-alpha therapies. Endoscopic improvement was observed in 11 of 12 patients. Conclusions: CNIs may be promising treatment options for refractory intestinal BD.

KW - Calcineurin inhibitor

KW - Cyclosporin

KW - Intestinal Behçet's disease

KW - Tacrolimus

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Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet's Disease

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