Efficacy of carbon monoxide laser in selectively intimal themal welding —Implications for Laser Balloon Angioplasty—

Akira Miyamoto, Masami Sakurada, Kyoichi Mizuno, Akira Kurita, Haruo Nakamura, Tsunenori Arai, Makoto Kikuchi

研究成果: Article査読

1 被引用数 (Scopus)


Excessive vascular damage causes excessive vascular repair, which results in restenosis. To limit the thickness of the coagulation layer in laser balloon angioplasty, we used a carbon monoxide (CO) laser, which has high tissue absorption, as a therapy laser source instead of a Nd: YAG laser. To investigate the benefit of short-penetration CO laser light to vascular tissue, excised human abdominal aorta was irradiated with a CO laser through a 30 μm polyethylene membrane. The temperature of the vascular tissue was continuously monitored during irradiation. CO laser irradiation of 20 W/cm2 was performed in either a continuous mode or an intermittent mode with various duty ratios (exposure/interval duration). With a total fluence of 200 J/cm2, the adventitial temperature decreased as the duty ratio was reduced. The adventitial temperature at a duty ratio of 1 : 2 was 43°C. Microscopic examination of aorta which had been intermittently irradiated duty ratio of 1 : 2 showed thermal coagulation localized within the intima and a flattened intimal surface. These results suggest that intermittent laser irradiation with a CO laser can be used to limit the depth of thermal coagulation, and can selectively weld the intima without excessive thermal damage. Laser balloon angioplasty using a CO laser may help to prevent restenosis.

出版ステータスPublished - 1993

ASJC Scopus subject areas

  • 生理学
  • 循環器および心血管医学


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