TY - JOUR
T1 - Efficacy of the Milan criteria as a prognostic factor in patients with colorectal liver metastases
AU - Chiba, Naokazu
AU - Abe, Yuta
AU - Koganezawa, Itsuki
AU - Nakagawa, Masashi
AU - Yokozuka, Kei
AU - Ozawa, Yosuke
AU - Kobayashi, Toshimichi
AU - Sano, Toru
AU - Tomita, Koichi
AU - Tsutsui, Rina
AU - Kawachi, Shigeyuki
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
PY - 2021/6
Y1 - 2021/6
N2 - Purpose: This study aimed to apply the principles of the “Milan criteria” to patients undergoing hepatic resection for CRLM and to evaluate the efficacy of prognostic factors. Methods: The medical records of consecutive patients who underwent curative resection for CRLM from April 2007 to April 2019 were retrospectively reviewed. Time to aggressive treatment failure (TATF) was defined as the time interval from the initial surgery until the first unresectable recurrence or recurrence that could only be treated with doublet or lower dose chemotherapy, or death. The risk factors associated with recurrence-free survival (RFS), TSF, TATF, and overall survival (OS) were evaluated. Results: On univariate analysis, the Milan criteria significantly predicted long-term OS, TATF, TSF, and RFS. Moreover, the Milan criteria were able to stratify patients with CRLM into distinct prognostic groups with regard to long-term OS, TATF, TSF, and RFS. Conclusions: Milan criteria, a simple index, are a factor contributing to all the survival time and are a very important factor in discussing the prognosis of CRLM.
AB - Purpose: This study aimed to apply the principles of the “Milan criteria” to patients undergoing hepatic resection for CRLM and to evaluate the efficacy of prognostic factors. Methods: The medical records of consecutive patients who underwent curative resection for CRLM from April 2007 to April 2019 were retrospectively reviewed. Time to aggressive treatment failure (TATF) was defined as the time interval from the initial surgery until the first unresectable recurrence or recurrence that could only be treated with doublet or lower dose chemotherapy, or death. The risk factors associated with recurrence-free survival (RFS), TSF, TATF, and overall survival (OS) were evaluated. Results: On univariate analysis, the Milan criteria significantly predicted long-term OS, TATF, TSF, and RFS. Moreover, the Milan criteria were able to stratify patients with CRLM into distinct prognostic groups with regard to long-term OS, TATF, TSF, and RFS. Conclusions: Milan criteria, a simple index, are a factor contributing to all the survival time and are a very important factor in discussing the prognosis of CRLM.
KW - Colorectal liver metastases
KW - Milan criteria
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U2 - 10.1007/s00423-021-02088-x
DO - 10.1007/s00423-021-02088-x
M3 - Article
C2 - 33604821
AN - SCOPUS:85100982772
SN - 1435-2443
VL - 406
SP - 1129
EP - 1138
JO - Langenbeck's Archives of Surgery
JF - Langenbeck's Archives of Surgery
IS - 4
ER -