Enhanced expression of B7.2 (CD86) by percutaneous sensitization with house dust mite antigen

Kazuki Santa, Kenji Watanabe, Tsutomu Nakada, Hiroyuki Kato, Sonoko Habu, Shunichiro Kubota

研究成果: Article査読

6 被引用数 (Scopus)

抄録

House dust mite antigen is a well-known allergen in the pathogenesis of atopic dermatitis (AD), a chronic relapsing inflammatory skin disease. We evaluated the AD model mice sensitized with house dust mite antigen and observed a Th2-dominant immune response. In this experiment, BALB/c mice were sensitized percutaneously with house dust mite antigen three times with 7 days interval after skin barrier disruption. A remarkable infiltration of polymorphonuclear granulocytes and monocytes in the cutis was observed in mice treated with this antigen, high serum IgE levels and IL-4 mRNA expression in local lymph node cells was also observed. CD19+ B cell numbers overturned to CD4+ helper T cells. In these mice, there was significant increase of B7.2 (CD86) expression on CD19+ B cells. These results indicate that house dust mite antigen sensitizes BALB/c mice and skews their Th1/Th2 balance toward Th2.

本文言語English
ページ(範囲)5-12
ページ数8
ジャーナルImmunology Letters
85
1
DOI
出版ステータスPublished - 2003 1月 2
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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