Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

Junko Kizu; Motoki Arakawa; Yoshihiro Arakawa; Fusako Komoda; Masaru Takamizawa; Tsutomu Iwata; Tetsuo Hayakawa; Kazuhiro Imai

doi:10.1002/(SICI)1099-0801(199911)13:7<462::AID-BMC912>3.0.CO;2-P

Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

Junko Kizu, Motoki Arakawa, Yoshihiro Arakawa, Fusako Komoda, Masaru Takamizawa, Tsutomu Iwata, Tetsuo Hayakawa, Kazuhiro Imai

研究成果: Article › 査読

1 被引用数 (Scopus)

抄録

The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow-release preparation of TP. The ratios of the plasma levels of these metabolites to TP levels in the group aged 1-4 years were larger than those in the group aged 5 years and older, suggesting enhanced activity of drug-metabolizing enzymes during infancy.

本文言語	English
ページ（範囲）	462-464
ページ数	3
ジャーナル	Biomedical Chromatography
巻	13
号	7
DOI	https://doi.org/10.1002/(SICI)1099-0801(199911)13:7<462::AID-BMC912>3.0.CO;2-P
出版ステータス	Published - 1999
外部発表	はい

ASJC Scopus subject areas

分析化学
生化学
分子生物学
薬理学
創薬
臨床生化学

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10.1002/(SICI)1099-0801(199911)13:7<462::AID-BMC912>3.0.CO;2-P

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author = "Junko Kizu and Motoki Arakawa and Yoshihiro Arakawa and Fusako Komoda and Masaru Takamizawa and Tsutomu Iwata and Tetsuo Hayakawa and Kazuhiro Imai",

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AU - Kizu, Junko

AU - Arakawa, Motoki

AU - Arakawa, Yoshihiro

AU - Komoda, Fusako

AU - Takamizawa, Masaru

AU - Iwata, Tsutomu

AU - Hayakawa, Tetsuo

AU - Imai, Kazuhiro

PY - 1999

Y1 - 1999

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AB - The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow-release preparation of TP. The ratios of the plasma levels of these metabolites to TP levels in the group aged 1-4 years were larger than those in the group aged 5 years and older, suggesting enhanced activity of drug-metabolizing enzymes during infancy.

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Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under

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