TY - JOUR
T1 - Enhancement of CDP-DG:inositol transferase activity in src- and erbB2- transformed cells
AU - Imoto, Masaya
AU - Taniguchi, Yoshiko
AU - Fujiwara, Hiroaki
AU - Umezawa, Kazuo
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Phosphatidylinositol (PI) synthesis was activated in Rous sarcoma virus- infected NIH3T3 or activated erbB2-transformed NIH3T3 cells. The in vitro activity of CDP-DG:inositol transferase prepared from these cells was also higher than that from normal parent NIH3T3 cells, although phospholipase C and PI kinase activities were not significantly different among these cells. A tyrosine kinase inhibitor, erbstatin, inhibited the PI synthesis in cultured cells, suggesting that Src and ErbB2-associated tyrosine kinases are involved in activation of CDP-DG:inositol transferase in these cell lines.
AB - Phosphatidylinositol (PI) synthesis was activated in Rous sarcoma virus- infected NIH3T3 or activated erbB2-transformed NIH3T3 cells. The in vitro activity of CDP-DG:inositol transferase prepared from these cells was also higher than that from normal parent NIH3T3 cells, although phospholipase C and PI kinase activities were not significantly different among these cells. A tyrosine kinase inhibitor, erbstatin, inhibited the PI synthesis in cultured cells, suggesting that Src and ErbB2-associated tyrosine kinases are involved in activation of CDP-DG:inositol transferase in these cell lines.
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U2 - 10.1006/excr.1994.1129
DO - 10.1006/excr.1994.1129
M3 - Article
C2 - 7909754
AN - SCOPUS:0028239128
SN - 0014-4827
VL - 212
SP - 151
EP - 154
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 1
ER -