Epstein-Barr virus-associated lymphoepithelial carcinoma arising in the parotid gland: A case report and literature review

Akinobu Kubota, Nobuyuki Bandoh, Takashi Goto, Ken Ichi Matsumoto, Tomomi Yamaguchi-Ishochi, Yasutaka Kato, Hiroshi Nishihara, Hidehiro Takei

研究成果: Article査読

抄録

A 60-year-old woman presented with a 3-year history of a slow-growing, painless mass in their left parotid gland. Ult rasonography revealed a well-ci rcumscribed, lobulated, hypoechoic mass measuring 19x12x10 mm in the left parotid gland. Computed tomography revealed a well-circumscribed, solid mass with homogeneous enhance-ment. Fluorodeoxyglucose-positron emission tomography revealed uptake by the tumor but no uptake in other organs, including the nasopharynx. The patient underwent superficial parotidectomy with adequate safety margins and selective neck dissection followed by radiotherapy. No facial paralysis or recurrence of the tumor had been observed as of 20 months post-operation. Histologically, the tumor was composed of sheets of syncytial cancer cells with prominent nucleoli in a dense lymphoplasmacytic background. Epstein-Barr virus (EBV)-encoded RNA in situ hybridization was diffusely positive in the tumor cells. These findings indicated that the tumor was an EBV-associated lymphoepithelial carcinoma. Metastasis, especially from the nasopharynx, was excluded endoscopically and radiologically. Targeted next-generation sequencing of 160 cancer-related genes using the surgical specimen revealed no mutations, including known significant mutations detected in EBV-associated nasopharyngeal carcinoma.

本文言語English
論文番号24
ジャーナルMolecular and Clinical Oncology
18
3
DOI
出版ステータスPublished - 2023 3月

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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