TY - JOUR
T1 - Establishment of an immortalized human endometrial stromal cell line with functional responses to ovarian stimuli
AU - Yuhki, Munehiro
AU - Kajitani, Takashi
AU - Mizuno, Takakazu
AU - Aoki, Yuko
AU - Maruyama, Tetsuo
PY - 2011/8/1
Y1 - 2011/8/1
N2 - Studies on the mechanisms of decidualization and endometriosis are often hampered by lack of primary endometrial cells. To facilitate in vitro studies, we established a human endometrial stromal cell line, KC02-44D, immortalized with human telomerase reverse transcriptase. Upon exposure to ovarian stimuli, KC02-44D cells showed similar cytoskeletal marker or gene expression and biochemical phenotype to primary endometrial stromal cells. KC02-44D would be useful for studies of human endometrial function and its associated pathologies.
AB - Studies on the mechanisms of decidualization and endometriosis are often hampered by lack of primary endometrial cells. To facilitate in vitro studies, we established a human endometrial stromal cell line, KC02-44D, immortalized with human telomerase reverse transcriptase. Upon exposure to ovarian stimuli, KC02-44D cells showed similar cytoskeletal marker or gene expression and biochemical phenotype to primary endometrial stromal cells. KC02-44D would be useful for studies of human endometrial function and its associated pathologies.
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UR - http://www.scopus.com/inward/citedby.url?scp=79960853676&partnerID=8YFLogxK
U2 - 10.1186/1477-7827-9-104
DO - 10.1186/1477-7827-9-104
M3 - Article
C2 - 21801462
AN - SCOPUS:79960853676
SN - 1477-7827
VL - 9
JO - Reproductive Biology and Endocrinology
JF - Reproductive Biology and Endocrinology
M1 - 104
ER -