Eudesmane-type sesquiterpenoid and guaianolides from Kandelia candel in a screening program for compounds to overcome TRAIL resistance

Tomohiro Minakawa; Kazufumi Toume; Midori A. Arai; Samir K. Sadhu; Firoj Ahmed; Masami Ishibashi

doi:10.1021/np300179c

Eudesmane-type sesquiterpenoid and guaianolides from Kandelia candel in a screening program for compounds to overcome TRAIL resistance

Tomohiro Minakawa
, Kazufumi Toume
, Midori A. Arai
, Samir K. Sadhu
, Firoj Ahmed
, Masami Ishibashi

研究成果: Article › 査読

17 被引用数 (Scopus)

抄録

In a screening program for natural products that can overcome TRAIL resistance, a new eudesmane-type sesquiterpenoid (1), three new guaianolides, mehirugins A-C (2-4), and two known guaianolides (5 and 6) were isolated from a MeOH extract of Kandelia candel leaves. Compounds 1 and 3-6 in combination with TRAIL showed cytotoxic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma cells.

本文言語	English
ページ（範囲）	1431-1435
ページ数	5
ジャーナル	Journal of Natural Products
巻	75
号	8
DOI	https://doi.org/10.1021/np300179c
出版ステータス	Published - 2012 8月 24
外部発表	はい

ASJC Scopus subject areas

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

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10.1021/np300179c

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引用スタイル

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