Evaluation of adrenaline auto-injector prescription profiles: A population-based, retrospective cohort study within the National Insurance Claims Database of Japan

Sakura Sato, Keigo Kainuma, Tatsuya Noda, Motohiro Ebisawa, Masaki Futamura, Tomoaki Imamura, Akihiro Miyagawa, Saeko Nakajima, Yasushi Ogawa, Takenori Inomata, Keiko Kan-o, Yosuke Kurashima, Katsunori Masaki, Tomoya Myojin, Yuichi Nishioka, Masafumi Sakashita, Mayumi Tamari, Hideaki Morita, Takeya Adachi

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Background: Adrenaline is the first-line medication for managing anaphylaxis. A better understanding of prescription trends for adrenaline auto-injectors (AAIs) is important to improving patient care as well as information on health education interventions and medical guidelines. However, it has been difficult to gather comprehensive data in a sustainable manner. Thus, we aimed to investigate trends in AAI prescriptions in Japan. Methods: We searched the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB), a unique and comprehensive database of health insurance claims, and investigated prescriptions for AAIs for all ages (April 2017 to March 2018). We assessed the annual number of prescriptions per person as well as prescription rates per 100,000 population per year by age, sex, and geographic region. Results: A total of 88,039 subjects (56,109 males, 31,930 female) and 116,758 devices (1.33 AAIs per patient per year) were prescribed AAIs at least once a year for all ages. The prescription rate for AAIs was 69.5 per 100,000 population-years. Patients aged 0–9 years were prescribed AAIs at the rate of 278.9 per 100,000 population-years. Patients aged 0–19 years were 6.4 times more likely to be prescribed AAIs than those over 20 years of age. Males were more frequently prescribed AAIs than females in all age groups, except for those aged 20–24 years. We also evaluated differences in prescription rates by geographic region. Conclusions: This comprehensive evaluation revealed trends in AAI prescriptions, thus helping develop preventive strategies with respect to anaphylaxis in Japan.

本文言語English
ページ(範囲)354-361
ページ数8
ジャーナルAllergology International
71
3
DOI
出版ステータスPublished - 2022 7月

ASJC Scopus subject areas

  • 免疫アレルギー学

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