@article{e255dc570ec64507a8967f503ff90d2a,
title = "Exaggerated secretion of atrial natriuretic polypeptide during dynamic exercise in patients with essential hypertension",
abstract = "The plasma concentration of atrial natriuretic polypeptide (ANP) was measured in nine patients with essential hypertension during two grades of exercise tests performed in the supine position on a bicycle ergometer. The plasma ANP concentration significantly increased from 97.0 ± 19.2 pg/ml to 107.6 ± 23.7 pg/ml (p < 0.05) during low-grade exercise (50% of the maximal heart rate) and from 96.2 ± 16.5 pg to 192.8 ± 30.7 pg/ml (p < 0.01) during high-grade exercise (75% of the maximal heart rate). During high-grade exercise plasma epinephrine and norepinephrine concentrations showed significant increases. The plasma ANP concentration was significantly correlated with systolic blood pressure (r = 0.51; p < 0.05). Patients with essential hypertension showed greater absolute increases in the plasma ANP concentration and systolic blood pressure during exercise compared to normotensive subjects. These results suggest that exercise stimulates secretion of ANP in response to its intensity in patients with essential hypertension and that a greater rise in atrial pressure, resulting from a greater elevation of systolic blood pressure, may be involved in the exaggerated secretion of ANP in patients with essential hypertension.",
author = "Yoshihiko Saito and Kazuwa Nakao and Akira Sugawara and Kazunobu Nishimura and Narito Morii and Takayuki Yamada and Hiroshi Itoh and Shozo Shiono and Masashi Mukoyama and Hiroshi Arai and Makoto Sakamoto and Toshihiko Ban and Hiroo Imura",
note = "Funding Information: From the Second Division, Department of Medicine, and the Department of Cardiovascular Surgery, Kyoto University School of Medicine, and the Radioisotope Research Center, Kyoto University. Supported in part by research grants from the Japanese Ministry Education, Science, and Culture, the Japanese Ministry of Health Welfare “Disorders of Adrenal Hormone” Research Committee, 1987; the Life Science Research Project of the Institute of Physical Chemical Research (RIKEN), Japan Tobacco Inc; and the Yamanouchi Foundation for Research on Metabolic Disorders; and by research grants for cardiovascular diseases (60A.3 and 62A{\textquoteright}-1) from the Japanese Ministry .c L J-,.1 ~.. -. .I. _.-_.__1 r.7 .1LAIY.C. 1c. Received for publication Dec. 17, 1987; revision accepted May 11, 1988. Reprint requests: Kazuwa Nakao, MD, PhD, Second Division, Department of Medicine, Kyoto University School of Medicine, Kyoto 606, Japan.",
year = "1988",
month = oct,
doi = "10.1016/0002-8703(88)90159-7",
language = "English",
volume = "116",
pages = "1052--1057",
journal = "American heart journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "4",
}