Executive dysfunction in medication-naïve children with ADHD: A multi-modal fNIRS and EEG study

Yoshimi Kaga, Riyo Ueda, Miho Tanaka, Yosuke Kita, Kota Suzuki, Yasuko Okumura, Yuka Egashira, Yuka Shirakawa, Shota Mitsuhashi, Yuzuki Kitamura, Eiji Nakagawa, Yushiro Yamashita, Masumi Inagaki

研究成果: Article査読

19 被引用数 (Scopus)


Objective: Children with attention deficit hyperactivity disorder (ADHD) exhibit deficits in executive function. Since there are no clear biomarkers for the disorder, this study aimed to investigate the neurophysiological biomarkers for deficits in executive function in children with ADHD using functional near-infrared spectroscopy (fNIRS) and electroencephalography. Methods: Twenty patients diagnosed with ADHD and 19 typically developing children (TDC; 8–11 years old) were included. Event related potentials (ERPs) were recorded using an electroencephalogram (EEG) and oxygenated hemoglobin concentrations (Oxy-Hb) were recorded using fNIRS during a colored Go/NoGo task, simultaneously. Latencies and amplitudes of NoGo-N2 and NoGo/Go-P3 tasks were measured using EEG. Results: Children with ADHD showed significantly decreased Oxy-Hb in the right frontal cortex as well as longer NoGo-P3 latencies and a decreased NoGo/Go-P3 amplitude. There was a significant positive correlation between the Oxy-Hb and NoGo/Go-P3 amplitude. Conclusions: These results suggest that children with ADHD experience executive dysfunction. Hemodynamic and electrophysiological findings during the Go/NoGo task might be useful as a biomarker of executive function. Significance: These findings have key implications for understanding the pathophysiology of deficits in executive function in ADHD.

ジャーナルBrain and Development
出版ステータスPublished - 2020 9月

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 発達神経科学
  • 臨床神経学


「Executive dysfunction in medication-naïve children with ADHD: A multi-modal fNIRS and EEG study」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。