Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes

Kyle L. Fort; Michiel Van De Waterbeemd; Dmitriy Boll; Maria Reinhardt-Szyba; Mikhail E. Belov; Eita Sasaki; Reinhard Zschoche; Donald Hilvert; Alexander A. Makarov; Albert J.R. Heck

doi:10.1039/c7an01629h

Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes

Kyle L. Fort
, Michiel Van De Waterbeemd
, Dmitriy Boll
, Maria Reinhardt-Szyba
, Mikhail E. Belov
, Eita Sasaki
, Reinhard Zschoche
, Donald Hilvert
, Alexander A. Makarov
, Albert J.R. Heck

研究成果: Article › 査読

104 被引用数 (Scopus)

抄録

Native mass spectrometry can provide insight into the structure of macromolecular biological systems. As analytes under investigation get larger and more complex, instrument capabilities need to be advanced. Herein, modifications to an Orbitrap Q Exactive Plus mass spectrometer that increase signal intensity, mass resolution, and maximum m/z measurable are described.

本文言語	English
ページ（範囲）	100-105
ページ数	6
ジャーナル	Analyst
巻	143
号	1
DOI	https://doi.org/10.1039/c7an01629h
出版ステータス	Published - 2018 1月 7
外部発表	はい

ASJC Scopus subject areas

分析化学
生化学
環境化学
分光学
電気化学

文献へのアクセス

10.1039/c7an01629h

他のファイルとリンク

引用スタイル

@article{b271420a7ae4489a868d756eceb85c7d,

title = "Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes",

abstract = "Native mass spectrometry can provide insight into the structure of macromolecular biological systems. As analytes under investigation get larger and more complex, instrument capabilities need to be advanced. Herein, modifications to an Orbitrap Q Exactive Plus mass spectrometer that increase signal intensity, mass resolution, and maximum m/z measurable are described.",

author = "Fort, \{Kyle L.\} and \{Van De Waterbeemd\}, Michiel and Dmitriy Boll and Maria Reinhardt-Szyba and Belov, \{Mikhail E.\} and Eita Sasaki and Reinhard Zschoche and Donald Hilvert and Makarov, \{Alexander A.\} and Heck, \{Albert J.R.\}",

note = "Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

year = "2018",

month = jan,

day = "7",

doi = "10.1039/c7an01629h",

language = "English",

volume = "143",

pages = "100--105",

journal = "Analyst",

issn = "0003-2654",

publisher = "Royal Society of Chemistry",

number = "1",

}

TY - JOUR

T1 - Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes

AU - Fort, Kyle L.

AU - Van De Waterbeemd, Michiel

AU - Boll, Dmitriy

AU - Reinhardt-Szyba, Maria

AU - Belov, Mikhail E.

AU - Sasaki, Eita

AU - Zschoche, Reinhard

AU - Hilvert, Donald

AU - Makarov, Alexander A.

AU - Heck, Albert J.R.

PY - 2018/1/7

Y1 - 2018/1/7

N2 - Native mass spectrometry can provide insight into the structure of macromolecular biological systems. As analytes under investigation get larger and more complex, instrument capabilities need to be advanced. Herein, modifications to an Orbitrap Q Exactive Plus mass spectrometer that increase signal intensity, mass resolution, and maximum m/z measurable are described.

AB - Native mass spectrometry can provide insight into the structure of macromolecular biological systems. As analytes under investigation get larger and more complex, instrument capabilities need to be advanced. Herein, modifications to an Orbitrap Q Exactive Plus mass spectrometer that increase signal intensity, mass resolution, and maximum m/z measurable are described.

UR - https://www.scopus.com/pages/publications/85038610350

UR - https://www.scopus.com/pages/publications/85038610350#tab=citedBy

U2 - 10.1039/c7an01629h

DO - 10.1039/c7an01629h

M3 - Article

C2 - 29138777

AN - SCOPUS:85038610350

SN - 0003-2654

VL - 143

SP - 100

EP - 105

JO - Analyst

JF - Analyst

IS - 1

ER -

Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes

抄録

ASJC Scopus subject areas

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル