TY - JOUR
T1 - Experimental techniques for the development of a uterus transplantation model in cynomolgus macaques
AU - Kisu, Iori
AU - Banno, Kouji
AU - Obara, Hideaki
AU - Kato, Yojiro
AU - Yamada, Yohei
AU - Matsubara, Kentaro
AU - Matoba, Yusuke
AU - Adachi, Masataka
AU - Emoto, Katsura
AU - Masugi, Yohei
AU - Saiki, Yoko
AU - Ishigaki, Hirohito
AU - Itagaki, Iori
AU - Kawamoto, Ikuo
AU - Iwatani, Chizuru
AU - Nakagawa, Takahiro
AU - Murase, Mitsuru
AU - Tsuchiya, Hideaki
AU - Nakagawa, Kenshi
AU - Shiina, Takashi
AU - Aoki, Daisuke
N1 - Funding Information:
This work was supported by the Adaptable and Seamless Technology Transfer Program through Target‐Driven Research and Development (A‐STEP), AMED (AS2525033N), the Japan Society for the Promotion of Science (JSPS) KAKENHI (grant number 17H05099) and Kanzawa Medical Research Foundation.
Funding Information:
This work was supported by the Adaptable and Seamless Technology Transfer Program through Target-Driven Research and Development (A-STEP), AMED (AS2525033N), the Japan Society for the Promotion of Science (JSPS) KAKENHI (grant number 17H05099) and Kanzawa Medical Research Foundation.
Publisher Copyright:
© 2020 Japan Society of Obstetrics and Gynecology
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Uterus transplantation (UTx) is now a treatment for women with uterine factor infertility to have a child. However, UTx is still largely at the experimental stage, and many medical issues remain unsolved. Therefore, adequate studies in large animals including non-human primates are required for validation of these issues. UTx research, especially in non-human primates, can provide important information for its full establishment in humans due to the anatomical and physiological similarities between the two. We accumulated data from UTx studies using cynomolgus macaques since 2009 and established autologous and allogeneic UTx models which led to deliveries after performing the procedure. In this paper, we summarized key points to develop UTx models in cynomolgus macaques based on our experience. UTx models in non-human primates can surely contribute new and beneficial knowledge in this field and can be useful for the further development of UTx in humans.
AB - Uterus transplantation (UTx) is now a treatment for women with uterine factor infertility to have a child. However, UTx is still largely at the experimental stage, and many medical issues remain unsolved. Therefore, adequate studies in large animals including non-human primates are required for validation of these issues. UTx research, especially in non-human primates, can provide important information for its full establishment in humans due to the anatomical and physiological similarities between the two. We accumulated data from UTx studies using cynomolgus macaques since 2009 and established autologous and allogeneic UTx models which led to deliveries after performing the procedure. In this paper, we summarized key points to develop UTx models in cynomolgus macaques based on our experience. UTx models in non-human primates can surely contribute new and beneficial knowledge in this field and can be useful for the further development of UTx in humans.
KW - cynomolgus macaque
KW - non-human primate
KW - uterine factor infertility
KW - uterine transplantation
KW - uterus transplantation
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U2 - 10.1111/jog.14477
DO - 10.1111/jog.14477
M3 - Article
C2 - 32924267
AN - SCOPUS:85090934724
SN - 1341-8076
VL - 46
SP - 2251
EP - 2260
JO - Journal of Obstetrics and Gynaecology Research
JF - Journal of Obstetrics and Gynaecology Research
IS - 11
ER -