抄録
The expression of matrix metalloproteinase-1 (MMP-1) gene and the presence of MMP-1 protein in gastric cancer were examined by in situ hybridization and immunohistochemistry. Expression of the interstitial collagenase (MMP-1) gene was detected within the stroma of the neoplastic glands, and infiltration of eosinophils was observed to be associated with regions of MMP-1 gene expression. The degree of eosinophilic infiltration correlated with the level of MMP-1 mRNA expression. Immunostaining showed localization of MMP-1 protein in the stromal cells, and additionally in the neoplastic glands. These findings indicate that the stromal cells may play an important role in the expression of MMP-1, and suggest a pathophysiological role for MMP-1 in the invasion and metastasis of gastric cancer.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 401-406 |
| ページ数 | 6 |
| ジャーナル | Japanese Journal of Cancer Research |
| 巻 | 88 |
| 号 | 4 |
| DOI | |
| 出版ステータス | Published - 1997 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 腫瘍学
- 癌研究
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
