TY - JOUR
T1 - Expression of Notch1 and Numb in small cell lung cancer
AU - Kikuchi, Hajime
AU - Sakakibara-Konishi, Jun
AU - Furuta, Megumi
AU - Yokouchi, Hiroshi
AU - Nishihara, Hiroshi
AU - Yamazaki, Shigeo
AU - Uramoto, Hidetaka
AU - Tanaka, Fumihiro
AU - Harada, Masao
AU - Akie, Kenji
AU - Sugaya, Fumiko
AU - Fujita, Yuka
AU - Takamura, Kei
AU - Kojima, Tetsuya
AU - Harada, Toshiyuki
AU - Higuchi, Mitsunori
AU - Honjo, Osamu
AU - Minami, Yoshinori
AU - Watanabe, Naomi
AU - Oizumi, Satoshi
AU - Suzuki, Hiroyuki
AU - Ishida, Takashi
AU - Dosaka-Akita, Hirotoshi
AU - Isobe, Hiroshi
AU - Munakata, Mitsuru
AU - Nishimura, Masaharu
PY - 2017
Y1 - 2017
N2 - Notch signaling in tumorigenesis functions as an oncogene or tumor suppressor according to the type of malignancy. Numb represses intracellular Notch signaling. Previous studies have demonstrated that Notch signaling suppresses the proliferation of small cell lung cancer (SCLC) cell lines. However, in SCLC, the association between Notch1 and Numb expression and clinicopathological factors or prognosis has remained unclear. In this study, we evaluated the expression of Notch1 and Numb in SCLC. We immunohistochemically assessed 125 SCLCs that were surgically resected at 16 institutions participating in either the Hokkaido Lung Cancer Clinical Study Group Trial (HOT) or the Fukushima Investigative Group for Healing Thoracic Malignancy (FIGHT) between 2003 and 2013. Correlations between Notch1 or Numb expression and various clinicopathological features were evaluated. Notch1 expression was associated with ECOG performance status. Numb expression was associated with age, sex, and pathological histology (SCLC or Combined SCLC). Analysis of cellular biological expression did not demonstrate a significant correlation between the expression of Notch1 and of Numb. Multivariate Cox regression analysis showed that high Notch1 expression was an independent favorable prognostic factor for SCLC(hazard ratio = 0.503, P = 0.023). High Notch1 expression, but not Numb expression, is associated with favorable prognosis in SCLC.
AB - Notch signaling in tumorigenesis functions as an oncogene or tumor suppressor according to the type of malignancy. Numb represses intracellular Notch signaling. Previous studies have demonstrated that Notch signaling suppresses the proliferation of small cell lung cancer (SCLC) cell lines. However, in SCLC, the association between Notch1 and Numb expression and clinicopathological factors or prognosis has remained unclear. In this study, we evaluated the expression of Notch1 and Numb in SCLC. We immunohistochemically assessed 125 SCLCs that were surgically resected at 16 institutions participating in either the Hokkaido Lung Cancer Clinical Study Group Trial (HOT) or the Fukushima Investigative Group for Healing Thoracic Malignancy (FIGHT) between 2003 and 2013. Correlations between Notch1 or Numb expression and various clinicopathological features were evaluated. Notch1 expression was associated with ECOG performance status. Numb expression was associated with age, sex, and pathological histology (SCLC or Combined SCLC). Analysis of cellular biological expression did not demonstrate a significant correlation between the expression of Notch1 and of Numb. Multivariate Cox regression analysis showed that high Notch1 expression was an independent favorable prognostic factor for SCLC(hazard ratio = 0.503, P = 0.023). High Notch1 expression, but not Numb expression, is associated with favorable prognosis in SCLC.
KW - Immunohistochemistry
KW - Notch1
KW - Numb
KW - Small cell lung cancer
KW - Surgery
UR - http://www.scopus.com/inward/record.url?scp=85012031522&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85012031522&partnerID=8YFLogxK
U2 - 10.18632/oncotarget.14411
DO - 10.18632/oncotarget.14411
M3 - Article
C2 - 28060745
AN - SCOPUS:85012031522
SN - 1949-2553
VL - 8
SP - 10348
EP - 10358
JO - Oncotarget
JF - Oncotarget
IS - 6
ER -
