TY - JOUR
T1 - Expression of the heparin-binding growth factor receptor genes in human megakaryocytic leukemia cells
AU - Katoh, Osamu
AU - Hattori, Yutaka
AU - Sato, Takeyuki
AU - Kimura, Akiro
AU - Kuramoto, Atsushi
AU - Sugimura, Takashi
AU - Terada, Masaaki
N1 - Funding Information:
Teruhiko Yoshida and Yukishige Yamada, Center Research Institute, for providing and we also thank Dr. Koichi Igarashi, Takeda Chemical Industries, Ltd., for the gift of the aFGF and bFGF cDNA probes. This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Health and Welfare and from the Ministry of Education and by a Grant-in-Aid from the Ministry of Health and Welfare for a Comprehensive lo-year Strategy for Cancer Control, Japan.
PY - 1992/2/28
Y1 - 1992/2/28
N2 - K- sam bek, N- sam flg and FGFR3 sam3 establish gene family of the receptors for heparin-binding growth factors (HBGFs) or FGFs. These mRNAs were detected in human leukemia cells, CMK, K562 and HEL, which have megakaryocytic phenotype or the potency to differentiate into megakaryocytic lineage. In CMK cells N- sam flg transcript level was enhanced by the culture with 12-O-tetradecanoylphorbol-13-acetate (TPA). cDNA-polymerase chain reaction identified K- sam bek mRNA in human platelets, suggesting the involvement of HBGFs in megakaryocytopoiesis and functions of platelets.
AB - K- sam bek, N- sam flg and FGFR3 sam3 establish gene family of the receptors for heparin-binding growth factors (HBGFs) or FGFs. These mRNAs were detected in human leukemia cells, CMK, K562 and HEL, which have megakaryocytic phenotype or the potency to differentiate into megakaryocytic lineage. In CMK cells N- sam flg transcript level was enhanced by the culture with 12-O-tetradecanoylphorbol-13-acetate (TPA). cDNA-polymerase chain reaction identified K- sam bek mRNA in human platelets, suggesting the involvement of HBGFs in megakaryocytopoiesis and functions of platelets.
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U2 - 10.1016/0006-291X(92)91612-T
DO - 10.1016/0006-291X(92)91612-T
M3 - Article
C2 - 1311927
AN - SCOPUS:0026603587
SN - 0006-291X
VL - 183
SP - 83
EP - 92
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -