抄録
In order to examine expression of the Tn antigen on erythroid cells from a patient with Tn syndrome, we applied a selective two phase liquid culture system for human erythroid progenitors in peripheral blood. The cells were analyzed with flow cytometry employing an anti-Tn antibody and a lectin of Vicia villosa which recognizes only the Tn determinant. In the second phase, the Tn antigen was expressed on the cultured cells from the patient on day 3 and Tn-positive cells reached 62.7% on day 9. On the other hand, Tn-positive cells were not detected in the volunteer's cultured cells. When the patient's cells were co-cultured with the cells from a healthy voluteer, the percentage of Tn-positive cells was much lower than the expected value, suggesting that the normal cells suppressed the expression of Tn antigen on the patient's cells.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 271-283 |
| ページ数 | 13 |
| ジャーナル | The Japanese Journal of Human Genetics |
| 巻 | 37 |
| 号 | 4 |
| DOI | |
| 出版ステータス | Published - 1992 12月 1 |
ASJC Scopus subject areas
- 遺伝学（臨床）
UN SDG
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