Fasciitis and myositis: An analysis of muscle-related complications caused by chronic GVHD after allo-SCT

K. Oda, C. Nakaseko, S. Ozawa, M. Nishimura, Y. Saito, F. Yoshiba, T. Yamashita, H. Fujita, H. Takasaki, H. Kanamori, A. Maruta, H. Sakamaki, S. Okamoto

研究成果: Article査読

54 被引用数 (Scopus)

抄録

The muscle-related complications of fasciitis and myositis, caused by chronic GVHD after Allo-SCT are relatively rare, but at times will severely impair a patient's quality of life (QOL). We performed a retrospective analysis in Japanese Allo-SCT recipients to identify the incidence, risk factors and clinical features of fasciitis and myositis. In 1967 patients who underwent Allo-SCT between January 1994 and March 2005 and survived beyond 90 days post transplantation, eight patients developed fasciitis and nine patients developed myositis, with a 5-year cumulative incidence of 0.55% and 0.54%, respectively. The median time from SCT to the development of fasciitis and myositis was 991 and 660 days, respectively. PBSCT was a risk factor for developing fasciitis, but no risk factors were found for myositis. The response to immunosuppressive treatment was better in patients with myositis than fasciitis, and the overall survival after developing these symptoms was better in patients with myositis than those with fasciitis. An early diagnosis by a biopsy, which includes fascia and muscle or magnetic resonance imaging (MRI) and prompt treatment may be important to prevent an impairment of the patient's QOL with persistent disability.

本文言語English
ページ(範囲)159-167
ページ数9
ジャーナルBone Marrow Transplantation
43
2
DOI
出版ステータスPublished - 2009
外部発表はい

ASJC Scopus subject areas

  • 血液学
  • 移植

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