@article{ce1bd8c6740e461380d23645a1860b4a,
title = "Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice",
abstract = "Transplantation of glial-rich neural progenitors has been demonstrated to attenuate motor neuron degeneration and disease progression in rodent models of mutant superoxide dismutase 1 (SOD1)-mediated amyotrophic lateral sclerosis (ALS). However, translation of these results into a clinical setting requires a renewable human cell source. Here, we derived glial-rich neural progenitors from human iPSCs and transplanted them into the lumbar spinal cord of ALS mouse models. The transplanted cells differentiated into astrocytes, and the treated mouse group showed prolonged lifespan. Our data suggest a potential therapeutic mechanism via activation of AKT signal. The results demonstrated the efficacy of cell therapy for ALS by the use of human iPSCs as cell source.",
author = "Takayuki Kondo and Misato Funayama and Kayoko Tsukita and Akitsu Hotta and Akimasa Yasuda and Satoshi Nori and Shinjiro Kaneko and Masaya Nakamura and Ryosuke Takahashi and Hideyuki Okano and Shinya Yamanaka and Haruhisa Inoue",
note = "Funding Information: We would like to express our sincere gratitude to all of our coworkers and collaborators; to Yoshiko Karatsu for technical assistance; to Yasuhiro Watanabe for technical advice; and to Katsura Noda and Kazumi Murai for their valuable administrative support. We thank Astellas Pharma Inc. for FK506. This study was supported in part by a grant from the Funding Program of World-Leading Innovative R&D on Science and Technology (FIRST Program) of the Japan Society for the Promotion of Science (S.Y.), from the Leading Project of MEXT (S.Y. and H.I.), from CREST (H.I.), and from a Grant-in-Aid for Scientific Research on Innovative Area {\textquoteleft}{\textquoteleft}Foundation of Synapse and Neurocircuit Pathology{\textquoteright}{\textquoteright} (22110007) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (H.I.). S.Y. is a member without salary of the scientific advisory board of iPS Academia Japan. H.O. is a paid scientific consultant to San Bio, Inc., Eisai Co., Ltd., and Daiichi Sankyo Co., Ltd. ",
year = "2014",
month = aug,
day = "12",
doi = "10.1016/j.stemcr.2014.05.017",
language = "English",
volume = "3",
pages = "242--249",
journal = "Stem cell reports",
issn = "2213-6711",
publisher = "Cell Press",
number = "2",
}
