Four genes for the calpain family locate on four distinct human chromosomes

Shigeo Ohno, S. Minoshima, J. Kudoh, R. Fukuyama, Y. Shimizu, S. Ohmi-Imajoh, N. Shimizu, K. Suzuki

研究成果: Article査読

51 被引用数 (Scopus)

抄録

Calcium dependent proteases (calpains. CAPNs, E.C.3.4.22.17) constitute a family of proteins which share a homologous cysteine-protease domain (large subunits. LI. L2. and L3) and an E-F hand Ca2+-binding domain (L1. L2. L3. and small subunit. S). We have mapped the genes for four calpain proteins (LI, L2, L3, and S) on four distinct human chromosomes by a combination of spot-blot hybridization to flow-sorted chromosomes and Southern hybridization of DNAs from a human × mouse hybrid cell panel. The genes for calpain LI (CAPN1. large subunit of calpain I). L2 (CAPN2, large subunit of calpain II), L3 (CAPN3. a protein related to the large subunits), and S (CAPN4. a small subunit common to calpains I and II) were assigned to human chromosomes 11, 1.15. and 19. respectively.

本文言語English
ページ(範囲)225-229
ページ数5
ジャーナルCytogenetics and Cell Genetics
53
4
DOI
出版ステータスPublished - 1990
外部発表はい

ASJC Scopus subject areas

  • 遺伝学
  • 細胞生物学

フィンガープリント

「Four genes for the calpain family locate on four distinct human chromosomes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル