@article{7dbedf546d414fa997264cb0a3ffcf5e,
title = "Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein",
abstract = "Foxp3+ regulatory T (Treg) cells limit pathogenic immune responses to self-antigens and foreign antigens. An essential role for microRNA (miRNA) in the maintenance and function of Treg cells, revealed by the Treg cell-specific Dicer ablation, raised a question as to a specific miRNA contribution. We found that Foxp3 controlled the elevated miR155 expression required for maintaining Treg cell proliferative activity and numbers under nonlymphopenic conditions. Moreover, miR155 deficiency in Treg cells resulted in increased suppressor of cytokine signaling 1 (SOCS1) expression accompanied by impaired activation of signal transducer and activator of transcription 5 (STAT5) transcription factor in response to limiting amounts of interleukin-2. Our studies suggest that Foxp3-dependent regulation of miR155 maintains competitive fitness of Treg cell subsets by targeting SOCS1, and they provide experimental support for a proposed role for miRNAs in ensuring the robustness of cellular phenotypes.",
keywords = "CELLIMMUNO, MOLIMMUNO",
author = "Lu, {Li Fan} and Thai, {To Ha} and Calado, {Dinis Pedro} and Ashutosh Chaudhry and Masato Kubo and Kentaro Tanaka and Loeb, {Gabriel B.} and Hana Lee and Akihiko Yoshimura and Klaus Rajewsky and Rudensky, {Alexander Y.}",
note = "Funding Information: We thank S. Josefowicz for the help in key experiments, T. Chu, L. Karpik, and K. Forbush for superb technical assistance, and all members of our laboratory for discussions. This work was supported by grants from the National Institutes of Health (to A.Y.R. and K.R.), from the European Union through MUGEN (to K.R.), and from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (to A.Y.). L.L.F. is a Leukemia and Lymphoma Society Fellow. D.P.C. is supported by the Portuguese Foundation for Science and Technology (FCR-MCES). A.Y.R. is a Howard Hughes Medical Institute investigator. ",
year = "2009",
month = jan,
day = "16",
doi = "10.1016/j.immuni.2008.11.010",
language = "English",
volume = "30",
pages = "80--91",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "1",
}
