We prepared hollow particles in nano size using a layer-by-layer deposition. Liposomes were used as a template for the layer-by-layer deposition. At first, negatively charged liposomes were prepared from dilauroyl phosphatidic acid (DLPA) and dimyristoyl phosphatidylcholine (DMPC). Poly-L-lysine (PLys) and poly-L-aspartic acid (PAsp) were used as adsorbates. When the alternative adsorption of PLys and PAsp on the liposomes was repeated for thickening the capsule layer, their ζ-potentials changed between positive and negative charges at each deposition. To investigate the release from liposomes and liposome-polypeptide complex, 1-hydroxypyrene-3,6,8-trisulfonic acid (HPTS) was incorporated. From the leakage experiment in a buffered solution, we found that the adsorption of polymers was related to the release from hollow particles, and the leakage was completely inhibited by the deposition above 400ppm of PLys.
|出版ステータス||Published - 2005 12月 1|
|イベント||54th SPSJ Annual Meeting 2005 - Yokohama, Japan|
継続期間: 2005 5月 25 → 2005 5月 27
|Other||54th SPSJ Annual Meeting 2005|
|Period||05/5/25 → 05/5/27|
ASJC Scopus subject areas