Functionalization of hollow nanoparticles fabricated by the layer-by-layer deposition

Tomonori Toyoda, Keiji Fujimoto

研究成果: Paper査読


We prepared hollow particles in nano size using a layer-by-layer deposition. Liposomes were used as a template for the layer-by-layer deposition. At first, negatively charged liposomes were prepared from dilauroyl phosphatidic acid (DLPA) and dimyristoyl phosphatidylcholine (DMPC). Poly-L-lysine (PLys) and poly-L-aspartic acid (PAsp) were used as adsorbates. When the alternative adsorption of PLys and PAsp on the liposomes was repeated for thickening the capsule layer, their ζ-potentials changed between positive and negative charges at each deposition. To investigate the release from liposomes and liposome-polypeptide complex, 1-hydroxypyrene-3,6,8-trisulfonic acid (HPTS) was incorporated. From the leakage experiment in a buffered solution, we found that the adsorption of polymers was related to the release from hollow particles, and the leakage was completely inhibited by the deposition above 400ppm of PLys.

出版ステータスPublished - 2005 12月 1
イベント54th SPSJ Annual Meeting 2005 - Yokohama, Japan
継続期間: 2005 5月 252005 5月 27


Other54th SPSJ Annual Meeting 2005

ASJC Scopus subject areas

  • 工学(全般)


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