Fundamental and clinical studies of cefotiam in the field of pediatrics

Hironobu Akita, Yukio Iwasaki, Satoshi Iwata, Takafumi Kanemitsu, Haruki Hattori, Keiji Jozaki, Masahiro Hotta, Naoya Yamashita, Seiichiro Nanri, Yoshibumi Kojima, Noriyoshi Hara, Keisuke Sunagawa, Tadao Oikawa, Takashi Iwata, Mitsuru Osano, Yasuo Ichihashi

研究成果: Article査読

5 被引用数 (Scopus)


The fundamental and clinical studies on cefotiam (CTM) were performed in the field of pediatrics, and the following results were obtained: 1. The peak MICs of CTM against Gram negative rods such as E. coli, Klebsiella, Salmonella, Proteus were 1.56mcg/ml. The MIC distribution against S. aureus was almost equal to the conventional cephalosporin antibiotics. The MICs against P. seudomonas and Serratia were over 400mcg/ml. 2. The mean serum levels of CTM after bolus intravenous injection of 25mg/kg were 59.9mg/ml after 15 min., 30.0mcg/ml after 30min., 15.6mcg/ml after 1 hour. 3. Administration of CTM to 6 pediatric patients produced the clinical responses which were good in all 6 cases and the bacterial effects of eradication in 3 cases and superinfection in the 2 cases in the 5 cases from whom the organism were isolated. No side effect was observed. From the above results, it is considered that a bolus injection of CTM 25 mg/kg t. i. d. to q. i. d. is a safe and useful treatment for pediatric cases.

ジャーナルthe japanese journal of antibiotics
出版ステータスPublished - 1981

ASJC Scopus subject areas

  • 微生物学(医療)
  • 薬理学(医学)
  • 感染症


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