Galectin-3 as a regulator of the epithelial junction: Implications to wound repair and cancer

Pablo Argüeso; Jerome Mauris; Yuichi Uchino

doi:10.1080/21688370.2015.1026505

Galectin-3 as a regulator of the epithelial junction: Implications to wound repair and cancer

Pablo Argüeso
, Jerome Mauris
, Yuichi Uchino

研究成果: Article › 査読

27 被引用数 (Scopus)

抄録

Epithelial cells are closely connected to each other and to the extracellular matrix by a set of adhesive contacts that provide tissues with unique barrier properties and play a prominent role in cell morphology, tissue physiology, and cell signaling. This review highlights advances made in understanding the contributions of galectin-3, a carbohydrate-binding protein with affinity toward β-galactosides, as a modulator of epithelial junction assembly and function. The interactions of galectin-3 within adhesive structures are discussed in relation to wound healing and tumor progression.

本文言語	English
ページ（範囲）	1-6
ページ数	6
ジャーナル	Tissue Barriers
巻	3
号	3
DOI	https://doi.org/10.1080/21688370.2015.1026505
出版ステータス	Published - 2015 7月 3
外部発表	はい

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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ASJC Scopus subject areas

生化学
組織学
細胞生物学

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10.1080/21688370.2015.1026505

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AU - Argüeso, Pablo

AU - Mauris, Jerome

AU - Uchino, Yuichi

N1 - Funding Information: This work was supported by a grant from the National Eye Institute of the National Institutes of Health (R01EY024031 to P. Argu€eso). Publisher Copyright: © 2015, © Taylor & Francis Group, LLC.

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Y1 - 2015/7/3

N2 - Epithelial cells are closely connected to each other and to the extracellular matrix by a set of adhesive contacts that provide tissues with unique barrier properties and play a prominent role in cell morphology, tissue physiology, and cell signaling. This review highlights advances made in understanding the contributions of galectin-3, a carbohydrate-binding protein with affinity toward β-galactosides, as a modulator of epithelial junction assembly and function. The interactions of galectin-3 within adhesive structures are discussed in relation to wound healing and tumor progression.

AB - Epithelial cells are closely connected to each other and to the extracellular matrix by a set of adhesive contacts that provide tissues with unique barrier properties and play a prominent role in cell morphology, tissue physiology, and cell signaling. This review highlights advances made in understanding the contributions of galectin-3, a carbohydrate-binding protein with affinity toward β-galactosides, as a modulator of epithelial junction assembly and function. The interactions of galectin-3 within adhesive structures are discussed in relation to wound healing and tumor progression.

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KW - epithelial junction

KW - galectin-3

KW - matrix metalloproteinases

KW - wound healing

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Galectin-3 as a regulator of the epithelial junction: Implications to wound repair and cancer

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UN SDG

ASJC Scopus subject areas

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