@inproceedings{5697d54d54544c9eb0dc46aa992af26c,
title = "Gene transfer of human hepatocyte growth factor by the use of nanosecond pulsed laser-induced stress waves",
abstract = "We successfully delivered a therapeutic vector construct, which carries hepatocyte growth factor (HGF) gene, to rat skin in vivo. After HGF expression vector had been intradermally injected to rat skin, LISWs were generated by irradiating the laser target put on the rat skin with nanosecond pulses from the second harmonics (532 nm) of a Q-switched Nd:YAG laser. Concentration of HGF protein increased by a factor of four by the application of LISWs when compared with that of control samples without LISW application. We also investigated the effects of LISWs on the integrity of plasmid DNA.",
keywords = "Electrophoresis, Gene therapy, Gene transfer, HGF, Laser, Plasmid DNA, Skin, Stress wave",
author = "Mitsuhiro Terakawa and Shunichi Sato and Daizoh Saitoh and Makoto Hasegawa and Hiroshi Ashida and Hideyuki Okano and Minoru Obara",
year = "2006",
month = aug,
day = "23",
doi = "10.1117/12.668965",
language = "English",
isbn = "0819463264",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
booktitle = "High-Power Laser Ablation VI",
note = "High-Power Laser Ablation VI ; Conference date: 07-05-2006 Through 12-05-2006",
}