TY - JOUR
T1 - Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus
AU - Maeda, Shiro
AU - Tsukada, Shuichi
AU - Kanazawa, Akio
AU - Sekine, Akihiro
AU - Tsunoda, Tatsuhiko
AU - Koya, Daisuke
AU - Maegawa, Hiroshi
AU - Kashiwagi, Atsunori
AU - Babazono, Tetsuya
AU - Matsuda, Masafumi
AU - Tanaka, Yasushi
AU - Fujioka, Tomoaki
AU - Hirose, Hiroshi
AU - Eguchi, Takashi
AU - Ohno, Yoichi
AU - Groves, Christopher J.
AU - Hattersley, Andrew T.
AU - Hitman, Graham A.
AU - Walker, Mark
AU - Kaku, Kohei
AU - Iwamoto, Yasuhiko
AU - Kawamori, Ryuzo
AU - Kikkawa, Ryuichi
AU - Kamatani, Naoyuki
AU - McCarthy, Mark I.
AU - Nakamura, Yusuke
PY - 2005/8
Y1 - 2005/8
N2 - To search a gene(s) conferring susceptibility to type 2 diabetes mellitus, we genotyped nearly 60,000 gene-based SNPs for Japanese patients and found evidence that the gene at chromosome 6p12 encoding transcription-factor- activating protein 2β (TFAP2B) was a likely candidate in view of significant association of polymorphism in this gene with type 2 diabetes. Extensive analysis of this region identified that several variations within TFAP2B were significantly associated with type 2 diabetes [a variable number of tandem repeat locus: χ2=10.9, P=0.0009; odds ratio=1.57, 95% CI 1.20-2.06, intron 1+774 (G/T); χ2=11.6, P=0.0006; odds ratio=1.60, 95% CI 1.22-2.09, intron 1+2093 (A/C); χ2=12.2, P=0.0004; odds ratio=1.61, 95% CI 1.23-2.11]. The association of TFAP2B with type 2 diabetes was also observed in the UK population. These results suggest that TFAP2B might be a new candidate for conferring susceptibility to type 2 diabetes and contribute to the pathogenesis of type 2 diabetes.
AB - To search a gene(s) conferring susceptibility to type 2 diabetes mellitus, we genotyped nearly 60,000 gene-based SNPs for Japanese patients and found evidence that the gene at chromosome 6p12 encoding transcription-factor- activating protein 2β (TFAP2B) was a likely candidate in view of significant association of polymorphism in this gene with type 2 diabetes. Extensive analysis of this region identified that several variations within TFAP2B were significantly associated with type 2 diabetes [a variable number of tandem repeat locus: χ2=10.9, P=0.0009; odds ratio=1.57, 95% CI 1.20-2.06, intron 1+774 (G/T); χ2=11.6, P=0.0006; odds ratio=1.60, 95% CI 1.22-2.09, intron 1+2093 (A/C); χ2=12.2, P=0.0004; odds ratio=1.61, 95% CI 1.23-2.11]. The association of TFAP2B with type 2 diabetes was also observed in the UK population. These results suggest that TFAP2B might be a new candidate for conferring susceptibility to type 2 diabetes and contribute to the pathogenesis of type 2 diabetes.
KW - Adipocytes
KW - Association study
KW - Single nucleotide polymorphism (SNP)
KW - Type 2 diabetes
KW - Variable number of tandem repeats (VNTR)
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U2 - 10.1007/s10038-005-0253-9
DO - 10.1007/s10038-005-0253-9
M3 - Article
C2 - 15940393
AN - SCOPUS:23844472598
SN - 1434-5161
VL - 50
SP - 283
EP - 292
JO - Journal of Human Genetics
JF - Journal of Human Genetics
IS - 6
ER -
