Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21

Kentaro Nagamine; Jun Kudoh; Shinsei Minoshima; Kazuhiko Kawasaki; Shuichi Asakawa; Fumiaki Ito; Nobuyoshi Shimizu

doi:10.1006/geno.1997.4761

Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21

Kentaro Nagamine
, Jun Kudoh
, Shinsei Minoshima
, Kazuhiko Kawasaki
, Shuichi Asakawa
, Fumiaki Ito
, Nobuyoshi Shimizu

研究成果: Article › 査読

5 被引用数 (Scopus)

抄録

The human PWP2 gene is the human homologue of the yeast periodic tryptophan protein 2 (PWP2) gene and is a member of the gene family that contains tryptophan-aspartate (WD) repeats. Genomic sequencing revealed that the human PWP2 gene consists of 21 exons spanning approximately 24 kb and locates just between the two genes EHOC-1 and KNP-I and distal to a NotI site of LJ104 (D21S1460) on chromosome 21q22.3. Analysis of the 5'-flanking DNA sequence revealed that the upstream region of the PWP2 gene is associated with a CpG island containing the NotI site of LJ104. Since PWP2 is considered to be a candidate for genetic disorders mapped in the 21q22.3 region, the information including nucleotide sequence and genomic organization of the PWP2 gene should be invaluable for the mutation analysis of the corresponding genetic disorders.

本文言語	English
ページ（範囲）	528-531
ページ数	4
ジャーナル	Genomics
巻	42
号	3
DOI	https://doi.org/10.1006/geno.1997.4761
出版ステータス	Published - 1997 6月 15
外部発表	はい

ASJC Scopus subject areas

遺伝学

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10.1006/geno.1997.4761

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title = "Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21",

abstract = "The human PWP2 gene is the human homologue of the yeast periodic tryptophan protein 2 (PWP2) gene and is a member of the gene family that contains tryptophan-aspartate (WD) repeats. Genomic sequencing revealed that the human PWP2 gene consists of 21 exons spanning approximately 24 kb and locates just between the two genes EHOC-1 and KNP-I and distal to a NotI site of LJ104 (D21S1460) on chromosome 21q22.3. Analysis of the 5'-flanking DNA sequence revealed that the upstream region of the PWP2 gene is associated with a CpG island containing the NotI site of LJ104. Since PWP2 is considered to be a candidate for genetic disorders mapped in the 21q22.3 region, the information including nucleotide sequence and genomic organization of the PWP2 gene should be invaluable for the mutation analysis of the corresponding genetic disorders.",

author = "Kentaro Nagamine and Jun Kudoh and Shinsei Minoshima and Kazuhiko Kawasaki and Shuichi Asakawa and Fumiaki Ito and Nobuyoshi Shimizu",

note = "Funding Information: The authors thank Drs. E. Nakato, K. Shibuya, and all the members of sequencing team for their contribution to this work, Dr. O. Gotoh for the nsm program, and Drs. H. Ichikawa and M. Ohki for the NotI linking clone. This work was supported in part by a Grant in Aid for Scienti{\textregistered}c Research on Priority Areas and Scienti{\textregistered}c Research from the Ministry of Education, Science, Sports and Culture of Japan, and the Fund for Human Genome Sequencing Project from the Japan Science and Technology Corporation (JST).",

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AU - Nagamine, Kentaro

AU - Kudoh, Jun

AU - Minoshima, Shinsei

AU - Kawasaki, Kazuhiko

AU - Asakawa, Shuichi

AU - Ito, Fumiaki

AU - Shimizu, Nobuyoshi

N1 - Funding Information: The authors thank Drs. E. Nakato, K. Shibuya, and all the members of sequencing team for their contribution to this work, Dr. O. Gotoh for the nsm program, and Drs. H. Ichikawa and M. Ohki for the NotI linking clone. This work was supported in part by a Grant in Aid for Scienti®c Research on Priority Areas and Scienti®c Research from the Ministry of Education, Science, Sports and Culture of Japan, and the Fund for Human Genome Sequencing Project from the Japan Science and Technology Corporation (JST).

PY - 1997/6/15

Y1 - 1997/6/15

N2 - The human PWP2 gene is the human homologue of the yeast periodic tryptophan protein 2 (PWP2) gene and is a member of the gene family that contains tryptophan-aspartate (WD) repeats. Genomic sequencing revealed that the human PWP2 gene consists of 21 exons spanning approximately 24 kb and locates just between the two genes EHOC-1 and KNP-I and distal to a NotI site of LJ104 (D21S1460) on chromosome 21q22.3. Analysis of the 5'-flanking DNA sequence revealed that the upstream region of the PWP2 gene is associated with a CpG island containing the NotI site of LJ104. Since PWP2 is considered to be a candidate for genetic disorders mapped in the 21q22.3 region, the information including nucleotide sequence and genomic organization of the PWP2 gene should be invaluable for the mutation analysis of the corresponding genetic disorders.

AB - The human PWP2 gene is the human homologue of the yeast periodic tryptophan protein 2 (PWP2) gene and is a member of the gene family that contains tryptophan-aspartate (WD) repeats. Genomic sequencing revealed that the human PWP2 gene consists of 21 exons spanning approximately 24 kb and locates just between the two genes EHOC-1 and KNP-I and distal to a NotI site of LJ104 (D21S1460) on chromosome 21q22.3. Analysis of the 5'-flanking DNA sequence revealed that the upstream region of the PWP2 gene is associated with a CpG island containing the NotI site of LJ104. Since PWP2 is considered to be a candidate for genetic disorders mapped in the 21q22.3 region, the information including nucleotide sequence and genomic organization of the PWP2 gene should be invaluable for the mutation analysis of the corresponding genetic disorders.

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Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21

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