TY - JOUR
T1 - Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3
AU - Nagamine, Kentaro
AU - Kudoh, Jun
AU - Kawasaki, Kazuhiko
AU - Minoshima, Shinsei
AU - Asakawa, Shuichi
AU - Ito, Fumiaki
AU - Shimizu, Nobuyoshi
N1 - Funding Information:
The authors thank Drs. E. Nakato and K. Shibuya, and all the members of genomic sequencing team in the Laboratory of Genomic Medicine for their contribution to this work. This work was supported in part by Fund for Human Genome Sequencing Project from the Japan Science and Technology Corporation (JST), and Grants in Aid for Scienti®c Research on Priority Areas and Scienti®c Research from the Ministry of Education, Science, Sports and Culture of Japan.
PY - 1997/6/9
Y1 - 1997/6/9
N2 - TMEM1 (EHOC-1) gene encodes a putative transmembrane protein and is located on human chromosome band 21q22.3. Analysis of a 122,638-bp genomic sequence revealed that TMEM1 gene consists of 23 exons spanning approximately 94 kb and is transcribed in the direction of centromere to telomere. The 5' region of the TMEM1 gene was associated with a CpG island and the 3' end of the TMEM1 gene was mapped just proximal to the 5' end of the neighboring gene PWP2. We determined that the TMEM1 gene encodes a protein of 1259 amino acids, which is 69-amino acids longer than the previously reported sequence. Since TMEM1 gene is considered to be a candidate for genetic disorders mapped in the 21q22.3 region, the information including complete nucleotide sequence and genomic organization of the TMEM1 gene should be invaluable for the mutation analysis of the corresponding genetic disorders.
AB - TMEM1 (EHOC-1) gene encodes a putative transmembrane protein and is located on human chromosome band 21q22.3. Analysis of a 122,638-bp genomic sequence revealed that TMEM1 gene consists of 23 exons spanning approximately 94 kb and is transcribed in the direction of centromere to telomere. The 5' region of the TMEM1 gene was associated with a CpG island and the 3' end of the TMEM1 gene was mapped just proximal to the 5' end of the neighboring gene PWP2. We determined that the TMEM1 gene encodes a protein of 1259 amino acids, which is 69-amino acids longer than the previously reported sequence. Since TMEM1 gene is considered to be a candidate for genetic disorders mapped in the 21q22.3 region, the information including complete nucleotide sequence and genomic organization of the TMEM1 gene should be invaluable for the mutation analysis of the corresponding genetic disorders.
UR - http://www.scopus.com/inward/record.url?scp=0031560924&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031560924&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1997.6758
DO - 10.1006/bbrc.1997.6758
M3 - Article
C2 - 9196060
AN - SCOPUS:0031560924
SN - 0006-291X
VL - 235
SP - 185
EP - 190
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -