Gorham-Stout Disease Resulting in Spinal Deformity Treated by Fusion Surgery Combined With Everolimus Therapy: A Case Report

Akira Toga; Kota Watanabe; Satoshi Suzuki; Satoshi Nori; Osahiko Tsuji; Narihito Nagoshi; Eijiro Okada; Mitsuru Yagi; Nobuyuki Fujita; Masaya Nakamura; Morio Matsumoto

doi:10.2106/JBJS.CC.20.00296

Gorham-Stout Disease Resulting in Spinal Deformity Treated by Fusion Surgery Combined With Everolimus Therapy: A Case Report

Akira Toga, Kota Watanabe, Satoshi Suzuki, Satoshi Nori, Osahiko Tsuji, Narihito Nagoshi, Eijiro Okada, Mitsuru Yagi, Nobuyuki Fujita, Masaya Nakamura, Morio Matsumoto

整形外科学

研究成果: Article › 査読

抄録

CASE: Gorham-Stout disease (GSD) is a rare disorder characterized by progressive localized osteolysis and lymphatic malformation. A 26-year-old woman with GSD presented to our hospital with a Cobb angle of 100° and a kyphosis angle of 88°. Everolimus therapy was initiated to control the disease prior to surgery. After halo-gravity traction for 4 weeks, we performed anterior and posterior spinal fusion. Postoperative computed tomography revealed satisfactory bone union and no significant loss of correction 1 year post-surgery. CONCLUSION: This case suggests that anterior and posterior spinal fusion combined with everolimus therapy can be a therapeutic option for GSD.

本文言語	English
ジャーナル	JBJS case connector
巻	11
号	1
DOI	https://doi.org/10.2106/JBJS.CC.20.00296
出版ステータス	Published - 2021 3月 3

ASJC Scopus subject areas

医学（全般）

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10.2106/JBJS.CC.20.00296

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abstract = "CASE: Gorham-Stout disease (GSD) is a rare disorder characterized by progressive localized osteolysis and lymphatic malformation. A 26-year-old woman with GSD presented to our hospital with a Cobb angle of 100° and a kyphosis angle of 88°. Everolimus therapy was initiated to control the disease prior to surgery. After halo-gravity traction for 4 weeks, we performed anterior and posterior spinal fusion. Postoperative computed tomography revealed satisfactory bone union and no significant loss of correction 1 year post-surgery. CONCLUSION: This case suggests that anterior and posterior spinal fusion combined with everolimus therapy can be a therapeutic option for GSD.",

author = "Akira Toga and Kota Watanabe and Satoshi Suzuki and Satoshi Nori and Osahiko Tsuji and Narihito Nagoshi and Eijiro Okada and Mitsuru Yagi and Nobuyuki Fujita and Masaya Nakamura and Morio Matsumoto",

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T2 - A Case Report

AU - Toga, Akira

AU - Watanabe, Kota

AU - Suzuki, Satoshi

AU - Nori, Satoshi

AU - Tsuji, Osahiko

AU - Nagoshi, Narihito

AU - Okada, Eijiro

AU - Yagi, Mitsuru

AU - Fujita, Nobuyuki

AU - Nakamura, Masaya

AU - Matsumoto, Morio

PY - 2021/3/3

Y1 - 2021/3/3

N2 - CASE: Gorham-Stout disease (GSD) is a rare disorder characterized by progressive localized osteolysis and lymphatic malformation. A 26-year-old woman with GSD presented to our hospital with a Cobb angle of 100° and a kyphosis angle of 88°. Everolimus therapy was initiated to control the disease prior to surgery. After halo-gravity traction for 4 weeks, we performed anterior and posterior spinal fusion. Postoperative computed tomography revealed satisfactory bone union and no significant loss of correction 1 year post-surgery. CONCLUSION: This case suggests that anterior and posterior spinal fusion combined with everolimus therapy can be a therapeutic option for GSD.

AB - CASE: Gorham-Stout disease (GSD) is a rare disorder characterized by progressive localized osteolysis and lymphatic malformation. A 26-year-old woman with GSD presented to our hospital with a Cobb angle of 100° and a kyphosis angle of 88°. Everolimus therapy was initiated to control the disease prior to surgery. After halo-gravity traction for 4 weeks, we performed anterior and posterior spinal fusion. Postoperative computed tomography revealed satisfactory bone union and no significant loss of correction 1 year post-surgery. CONCLUSION: This case suggests that anterior and posterior spinal fusion combined with everolimus therapy can be a therapeutic option for GSD.

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