Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species

M. J. Uddin; S. Kokubo; K. Ueda; K. Suenaga; D. Uemura

doi:10.1021/np010066n

Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species

M. J. Uddin, S. Kokubo, K. Ueda, K. Suenaga, D. Uemura

研究成果: Article › 査読

45 被引用数 (Scopus)

抄録

Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.

本文言語	English
ページ（範囲）	1169-1173
ページ数	5
ジャーナル	Journal of Natural Products
巻	64
号	9
DOI	https://doi.org/10.1021/np010066n
出版ステータス	Published - 2001 10月 16
外部発表	はい

ASJC Scopus subject areas

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

文献へのアクセス

10.1021/np010066n

他のファイルとリンク

引用スタイル

@article{157309bb53d24e4ab261deff461523b2,

title = "Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species",

abstract = "Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.",

author = "Uddin, {M. J.} and S. Kokubo and K. Ueda and K. Suenaga and D. Uemura",

year = "2001",

month = oct,

day = "16",

doi = "10.1021/np010066n",

language = "English",

volume = "64",

pages = "1169--1173",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "9",

}

TY - JOUR

T1 - Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species

AU - Uddin, M. J.

AU - Kokubo, S.

AU - Ueda, K.

AU - Suenaga, K.

AU - Uemura, D.

PY - 2001/10/16

Y1 - 2001/10/16

N2 - Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.

AB - Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.

UR - http://www.scopus.com/inward/record.url?scp=0034795861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034795861&partnerID=8YFLogxK

U2 - 10.1021/np010066n

DO - 10.1021/np010066n

M3 - Article

C2 - 11575950

AN - SCOPUS:0034795861

SN - 0163-3864

VL - 64

SP - 1169

EP - 1173

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species

抄録

ASJC Scopus subject areas

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル