Heme oxygenase-1 inhibits cytokine production by activated mast cells

Yumiko Yasui, Mao Nakamura, Toshihiro Onda, Tomohiro Uehara, Saori Murata, Nobuaki Matsui, Nobuyuki Fukuishi, Reiko Akagi, Makoto Suematsu, Masaaki Akagi

研究成果: Article査読

27 被引用数 (Scopus)


Heme oxygenase-1 (HO-1) is thought to contribute to host defense reactions against various stresses. In addition, recent reports have suggested that HO-1 modulates immunocyte activation and functions. HO-1 suppresses mast cell degranulation, but whether HO-1 suppresses cytokine synthesis as well is not yet known. We examined whether rat HO-1 cDNA transfected rat basophilic leukemia (RBL)-2H3 cells have altered cytokine production in response to stimulation with anti-ovalbumin (OA) serum/OA compared to Mock transfected RBL-2H3 cells. HO-1 inhibited anti-OA serum/OA-induced IL-3 and TNF-α production. Inhibition of HO-1 activity by Zn (II) protoporphyrin IX, a specific HO-1 inhibitor, prevented the suppression of TNF-α production. The cytokine inhibition by HO-1 was associated with selective suppression of the DNA-binding activity of AP-1 transcription factors. The suppression of mast cell cytokine production by HO-1 may be an important aspect of the processes that lead to resolution of allergic inflammation.

ジャーナルBiochemical and Biophysical Research Communications
出版ステータスPublished - 2007 3月 9

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学


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