Hemorrhagic onset of cerebellar pilocytic astrocytoma in an adult: A case report and review of the literature implying a possible relation of degenerative vascular changes to the massive intratumoral hemorrhage

Shunsuke Shibao, Tokuhiro Kimura, Hikaru Sasaki, Hirokazu Fujiwara, Takenori Akiyama, Mari Ueno, Satoka Shidoh, Kazunari Yoshida

研究成果: Review article査読

20 被引用数 (Scopus)

抄録

Pilocytic astrocytoma (PA) is a low-grade astrocytic tumor arising predominantly during the first two decades of life. Hemorrhagic onset of PAs is uncommon, and the etiology of hemorrhage remains unclear. Here we report a case of hemorrhagic onset of cerebellar PA in a 29-year-old man who presented with a week-long history of headache and gait instability. Computed tomography and magnetic resonance imaging revealed a hemorrhagic tumor located in the right cerebellar hemisphere, and total resection was performed. Histological examination showed bipolar glial cell proliferation in a biphasic pattern in a compact area and a loose microcystic area with Rosenthal fibers and eosinophilic granular bodies, indicating PA. Prominent changes in tumor vasculature, including aggregation of sclerotic thick-walled and ectatic thin-walled vessels, was observed, and nodules of thrombi containing complex vascular proliferation suggesting recanalized thrombi formed in partially ruptured vessels were also found. Thus, rupture of these abnormal vessels appeared to be the cause of hemorrhage. Review of the literature revealed that age distribution of patients with hemorrhagic PAs tends to be older than that of patients with general PAs. These findings imply a possibility that degenerative changes in blood vessels in long-standing PAs might be related to the mechanisms of spontaneous intratumoral hemorrhage.

本文言語English
ページ(範囲)96-102
ページ数7
ジャーナルBrain tumor pathology
29
2
DOI
出版ステータスPublished - 2012 4月

ASJC Scopus subject areas

  • 腫瘍学
  • 臨床神経学
  • 癌研究

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