Highly diastereo- and enantioselective direct aldol reactions in water

Yujiro Hayashi; Tatsunobu Sumiya; Junichi Takahashi; Hiroaki Gotoh; Tatsuya Urushima; Mitsuru Shoji

doi:10.1002/anie.200502488

Highly diastereo- and enantioselective direct aldol reactions in water

Yujiro Hayashi, Tatsunobu Sumiya, Junichi Takahashi, Hiroaki Gotoh, Tatsuya Urushima, Mitsuru Shoji

薬科学科

研究成果: Article › 査読

474 被引用数 (Scopus)

抄録

(Chemical Equation Presented) Going green: The synthetically very important aldol reaction can proceed in water without a metal catalyst with excellent enantioselectivity. The key to the reaction is a small, synthetic organic catalyst based on trans-hydroxyproline with a siloxy group. Thus, this method is an environmentally friendly process for the synthesis of chiral molecules.

本文言語	English
ページ（範囲）	958-961
ページ数	4
ジャーナル	Angewandte Chemie - International Edition
巻	45
号	6
DOI	https://doi.org/10.1002/anie.200502488
出版ステータス	Published - 2006 1月 30

ASJC Scopus subject areas

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化学 (全般)

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10.1002/anie.200502488

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AU - Urushima, Tatsuya

AU - Shoji, Mitsuru

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KW - Aldol reaction

KW - Asymmetric synthesis

KW - Diastereoselectivity

KW - Organocatalysis

KW - Solvent effects

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Highly diastereo- and enantioselective direct aldol reactions in water

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