Highly selective hydroxylation of benzene to phenol by wild-type cytochrome P450BM3 assisted by decoy molecules

Osami Shoji; Tatsuya Kunimatsu; Norifumi Kawakami; Yoshihito Watanabe

doi:10.1002/anie.201300282

Highly selective hydroxylation of benzene to phenol by wild-type cytochrome P450BM3 assisted by decoy molecules

Osami Shoji
, Tatsuya Kunimatsu
, Norifumi Kawakami
, Yoshihito Watanabe

研究成果: Article › 査読

135 被引用数 (Scopus)

抄録

Playing tricks on enzymes: Direct hydroxylation of benzene to phenol was catalyzed by wild-type P450BM3 in the presence of perfluorinated carboxylic acids as decoy molecules. The catalytic turnover rate reached 120 min ^-1 per P450. The selectivity towards phenol production was very high and no overoxidation products were detected.

本文言語	English
ページ（範囲）	6606-6610
ページ数	5
ジャーナル	Angewandte Chemie - International Edition
巻	52
号	26
DOI	https://doi.org/10.1002/anie.201300282
出版ステータス	Published - 2013 6月 24
外部発表	はい

ASJC Scopus subject areas

触媒
化学一般

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10.1002/anie.201300282

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abstract = "Playing tricks on enzymes: Direct hydroxylation of benzene to phenol was catalyzed by wild-type P450BM3 in the presence of perfluorinated carboxylic acids as decoy molecules. The catalytic turnover rate reached 120 min -1 per P450. The selectivity towards phenol production was very high and no overoxidation products were detected.",

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AU - Watanabe, Yoshihito

PY - 2013/6/24

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KW - carboxylic acid

KW - cytochromes

KW - decoy molecule

KW - hydroxylation

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U2 - 10.1002/anie.201300282

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Highly selective hydroxylation of benzene to phenol by wild-type cytochrome P450BM3 assisted by decoy molecules

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