TY - JOUR
T1 - Histological factors contributing to favorable prognoses of soft tissue sarcomas in premenopausal patients
AU - Ohsawa, Masahiko
AU - Aozasa, Katsuyuki
AU - Myoui, Akira
AU - Fujita, Masaki Q.
AU - Tsujimoto, Masahiko
AU - Ueda, Takafumi
AU - Uchida, Atsumasa
AU - Ono, Keiro
AU - Matsumoto, Keishi
N1 - Funding Information:
The autors thank Prof. E.H. Cooper (University of Leeds) for correcting the English. The work was supported in part by a grant from the Foundation for the Promotion of Cancer Research, Japan.
PY - 1991/4
Y1 - 1991/4
N2 - The correlations of sex with various histologic factors in soft tissue sarcomas (STS) were studied in 142 adult patients over the age of 20 years. They included 63 with malignant fibrous histiocytomas, 20 with liposarcomas, 20 with synovial sarcomas, 11 with malignant Schwannomas and 28 with other forms of STS. These were divided into four groups, according to age (20-49 years and ≥50 years) and sex. Survival rates in female patients were better than those in male patients, and the difference was significant between the 20-49 year groups (p<0.01). The relative frequencies in distribution of each histologic type were similar among male and female patients in both age groups. Among histological factors, mitotic counts showed a significant correlation (P< 0.04) with sex, followed by cellularity. STS in female patients aged 20-49 years had lower mitotic counts than in patients in other groups, where it occurred with a higher frequency of low and intermediate grade tumors. The findings suggested estrogen, either directly to indirectly, to have a favorable effect on STS prognosis in premenopausal female patients.
AB - The correlations of sex with various histologic factors in soft tissue sarcomas (STS) were studied in 142 adult patients over the age of 20 years. They included 63 with malignant fibrous histiocytomas, 20 with liposarcomas, 20 with synovial sarcomas, 11 with malignant Schwannomas and 28 with other forms of STS. These were divided into four groups, according to age (20-49 years and ≥50 years) and sex. Survival rates in female patients were better than those in male patients, and the difference was significant between the 20-49 year groups (p<0.01). The relative frequencies in distribution of each histologic type were similar among male and female patients in both age groups. Among histological factors, mitotic counts showed a significant correlation (P< 0.04) with sex, followed by cellularity. STS in female patients aged 20-49 years had lower mitotic counts than in patients in other groups, where it occurred with a higher frequency of low and intermediate grade tumors. The findings suggested estrogen, either directly to indirectly, to have a favorable effect on STS prognosis in premenopausal female patients.
KW - Estrogen
KW - Prognosis
KW - Sex
KW - Soft tissue sarcoma
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U2 - 10.1093/oxfordjournals.jjco.a039439
DO - 10.1093/oxfordjournals.jjco.a039439
M3 - Article
C2 - 2067125
AN - SCOPUS:0026149415
SN - 0368-2811
VL - 21
SP - 115
EP - 119
JO - Japanese journal of clinical oncology
JF - Japanese journal of clinical oncology
IS - 2
ER -
