How does the royal family of tudor rule the PIWI-interacting RNA pathway?

Mikiko C. Siomi, Taro Mannen, Haruhiko Siomi

研究成果: Review article査読

148 被引用数 (Scopus)


PIWI (F-element-induced wimpy testis) proteins are a subset of the Argonaute proteins and are expressed predominantly in the germlines of a variety of organisms, including Drosophila and mammals. FIWI proteins associate specifically with FIWI-interacting RNAs (piRNAs), small RNAs that are also expressed predominantly in germlines, and silence transposable DNA elements and other genes showing complementarities to the sequences of associated piRNAs. This mechanism helps to maintain the integrity of the genome and the development of gametes. PIWI proteins have been shown recently to contain symmetrical dimethyl arginines (sDMAs), and this modification is mediated by the methyltransferase PRMT5 (also known as Dart5 or Capsuleen). It was then demonstrated that multiple members of the Tudor (Tud) family of proteins, which are necessary for gametogenesis in both flies and mice, associate with FIWI proteins specifically through sDMAs in various but particular combinations. Although Tud domains in Tud family members are known to be sDMA-binding modules, involvement of the Tudor family at the molecular level in the piRNA pathway has only recently come into focus.

ジャーナルGenes and Development
出版ステータスPublished - 2010 4月 1

ASJC Scopus subject areas

  • 遺伝学
  • 発生生物学


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