Humanin affects object recognition and gliosis in short-term cuprizone-treated mice

Minetaka Murakami, Masatoshi Nagahama, Yoichiro Abe, Takako Niikura

研究成果: Article査読

10 被引用数 (Scopus)


Humanin (HN) is a 24-residue peptide that manipulates cell survival under various stresses. A highly potent HN derivative, HNG, reduced amyloid burden and neuroinflammation and suppressed cognitive impairment in Alzheimer's disease model mice. Cuprizone (CPZ), a copper chelator, provokes demyelination in the central nervous system of mice. A shorter (one week) exposure to CPZ induces schizophrenia-like behavior and glial activation prior to demyelination. We tested the effect of HNG on these short-term responses to CZP in mice. Intraperitoneal injection of HNG for one week improved object recognition memory but not working memory in CPZ-treated mice. Quantitative PCR analyses showed that HNG significantly suppressed CPZ-induced activation of microglia, but did not alter the reduced level of a myelin-specific transcript. These results suggest that HN can suppress neuroinflammation and the associated cognitive deficit in a wider range of neurological disorders beyond Alzheimer's disease.

出版ステータスPublished - 2017 12月 1

ASJC Scopus subject areas

  • 内分泌学
  • 神経学
  • 内分泌系および自律システム
  • 細胞および分子神経科学


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