抄録
Precipitation polymerization of N-isopropylacrylamide (NIPAM) with methylenebisacrylamide (MBAAm) in water at 70°C gave thermosensitive hydrogel microspheres. The adsorbability of proteins on the poly-NIPAM microspheres was found to depend on temperature. Below the lower critical solution temperature (LCST) of poly-NIPAM in an aqueous medium, that is, around 32°C, the microspheres hold a large amount of water inside and their surface is hydrophilic enough to suppress the adsorption of proteins. On the contrary, above 32°C, the micropheres deswell and their surface becomes hydrophobic and, consequently, susceptible to adsorption of a large amount of proteins. Proteins once adsorbed on the microspheres at a high temperature could be desorbed more or less by lowering the temperature to below 32°C. The extent of desorption at low temperatures was found to depend on the incubation time for adsorption at high temperatures.
本文言語 | English |
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ページ(範囲) | 53-57 |
ページ数 | 5 |
ジャーナル | Colloid & Polymer Science |
巻 | 270 |
号 | 1 |
DOI | |
出版ステータス | Published - 1992 1月 1 |
ASJC Scopus subject areas
- 物理化学および理論化学
- ポリマーおよびプラスチック
- コロイド化学および表面化学
- 材料化学