Hypermineralization of Hearing-Related Bones by a Specific Osteoblast Subtype

Yukiko Kuroda, Katsuhiro Kawaai, Naoya Hatano, Yanlin Wu, Hidekazu Takano, Atsushi Momose, Takuya Ishimoto, Takayoshi Nakano, Paul Roschger, Stéphane Blouin, Koichi Matsuo

研究成果: Article査読

7 被引用数 (Scopus)


Auditory ossicles in the middle ear and bony labyrinth of the inner ear are highly mineralized in adult mammals. Cellular mechanisms underlying formation of dense bone during development are unknown. Here, we found that osteoblast-like cells synthesizing highly mineralized hearing-related bones produce both type I and type II collagens as the bone matrix, while conventional osteoblasts and chondrocytes primarily produce type I and type II collagens, respectively. Furthermore, these osteoblast-like cells were not labeled in a “conventional osteoblast”-specific green fluorescent protein (GFP) mouse line. Type II collagen-producing osteoblast-like cells were not chondrocytes as they express osteocalcin, localize along alizarin-labeled osteoid, and form osteocyte lacunae and canaliculi, as do conventional osteoblasts. Auditory ossicles and the bony labyrinth exhibit not only higher bone matrix mineralization but also a higher degree of apatite orientation than do long bones. Therefore, we conclude that these type II collagen-producing hypermineralizing osteoblasts (termed here auditory osteoblasts) represent a new osteoblast subtype.

ジャーナルJournal of Bone and Mineral Research
出版ステータスPublished - 2021 8月

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 整形外科およびスポーツ医学


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