Hypofrontality in panic disorder and major depressive disorder assessed by multi-channel near-infrared spectroscopy.

Haruhisa Ohta, Bun Yamagata, Hiroi Tomioka, Taro Takahashi, Madoka Yano, Kazuyuki Nakagome, Masaru Mimura

研究成果: Article査読

49 被引用数 (Scopus)

抄録

BACKGROUND: Panic disorder is a common and debilitating psychiatric disease; yet, the neurobiology of this disorder is not fully understood. Deficits in the prefrontal inhibitory control over hyperactivity of the anxiety-related neural circuit are implicated in the pathophysiological core of panic disorder. The aims of this study were to investigate whether panic disorder reveals frontal lobe dysfunction while performing the word fluency test by using multi-channel near-infrared spectroscopy and to compare the findings in panic disorder with those in major depressive disorder. METHODS: Twenty-one patients with panic disorder, 17 patients with major depressive disorder, and 24 healthy control subjects participated in the study. RESULTS: Both patients with panic disorder and with major depressive disorder showed similarly attenuated increases in oxy-hemoglobin during the word fluency test in the bilateral frontal regions, when compared to healthy control participants. Hypofrontality in panic disorder and major depressive disorder was most prominent in the left medial inferior frontal lobe. CONCLUSIONS: This study clarified that hypofrontality in panic disorder is evident even with neutral stimuli of little emotional load.

本文言語English
ページ(範囲)1053-1059
ページ数7
ジャーナルDepression and anxiety
25
12
DOI
出版ステータスPublished - 2008
外部発表はい

ASJC Scopus subject areas

  • 臨床心理学
  • 精神医学および精神衛生

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