Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia

Kazuki Kiyose; Kenjiro Hanaoka; Daihi Oushiki; Tomomi Nakamura; Mayumi Kajimura; Makoto Suematsu; Hiroaki Nishimatsu; Takehiro Yamane; Takuya Terai; Yasunobu Hirata; Tetsuo Nagano

doi:10.1021/ja105937q

Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia

Kazuki Kiyose, Kenjiro Hanaoka, Daihi Oushiki, Tomomi Nakamura, Mayumi Kajimura, Makoto Suematsu, Hiroaki Nishimatsu, Takehiro Yamane, Takuya Terai, Yasunobu Hirata, Tetsuo Nagano

研究成果: Article › 査読

331 被引用数 (Scopus)

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Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.

本文言語	English
ページ（範囲）	15846-15848
ページ数	3
ジャーナル	Journal of the American Chemical Society
巻	132
号	45
DOI	https://doi.org/10.1021/ja105937q
出版ステータス	Published - 2010 11月 17

ASJC Scopus subject areas

触媒
化学一般
生化学
コロイド化学および表面化学

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10.1021/ja105937q

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AU - Kiyose, Kazuki

AU - Hanaoka, Kenjiro

AU - Oushiki, Daihi

AU - Nakamura, Tomomi

AU - Kajimura, Mayumi

AU - Suematsu, Makoto

AU - Nishimatsu, Hiroaki

AU - Yamane, Takehiro

AU - Terai, Takuya

AU - Hirata, Yasunobu

AU - Nagano, Tetsuo

PY - 2010/11/17

Y1 - 2010/11/17

N2 - Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.

AB - Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.

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Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia

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