Identification of 27-Nor-3a, 7α, 12α-Trihydroxycoprostan-24-One Apparently Derived from 3α, 7α, 12α-Trihydroxy-24-Oxocoprostanoic Acid, A Postulated Intermediate of Bile Acid Biosynthesis

Masatoshi Yuri; Marie Tokumoto; Noriyuki Hara; Yoshinori Fujimoto; Noriko Kobayashi; Masuo Morisaki

doi:10.1248/cpb.41.1327

Identification of 27-Nor-3a, 7α, 12α-Trihydroxycoprostan-24-One Apparently Derived from 3α, 7α, 12α-Trihydroxy-24-Oxocoprostanoic Acid, A Postulated Intermediate of Bile Acid Biosynthesis

Masatoshi Yuri, Marie Tokumoto, Noriyuki Hara, Yoshinori Fujimoto, Noriko Kobayashi, Masuo Morisaki

薬学科

研究成果: Article › 査読

12 被引用数 (Scopus)

抄録

Incubation of [27-¹³C]-3a,7a,12a-trihydroxycoprost-24-en-26-oic acid with rat liver homogenate followed by ^l3C-NMR analysis of the incubation product has resulted in the identification of [26-¹³C]-27-nor-3a,7a,12a-trihydroxycoprostan-24-one, supporting the idea that the substrate has been metabolized into 3a,7a,12a-trihydroxy-24-oxocoprostan-26-oic acid CoA derivative.

本文言語	English
ページ（範囲）	1327-1329
ページ数	3
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	41
号	7
DOI	https://doi.org/10.1248/cpb.41.1327
出版ステータス	Published - 1993 1月 1

ASJC Scopus subject areas

化学一般
創薬

文献へのアクセス

10.1248/cpb.41.1327

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フィンガープリント

「Identification of 27-Nor-3a, 7α, 12α-Trihydroxycoprostan-24-One Apparently Derived from 3α, 7α, 12α-Trihydroxy-24-Oxocoprostanoic Acid, A Postulated Intermediate of Bile Acid Biosynthesis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Yuri, M., Tokumoto, M., Hara, N., Fujimoto, Y., Kobayashi, N., & Morisaki, M. (1993). Identification of 27-Nor-3a, 7α, 12α-Trihydroxycoprostan-24-One Apparently Derived from 3α, 7α, 12α-Trihydroxy-24-Oxocoprostanoic Acid, A Postulated Intermediate of Bile Acid Biosynthesis. Chemical and Pharmaceutical Bulletin, 41(7), 1327-1329. https://doi.org/10.1248/cpb.41.1327

Identification of 27-Nor-3a, 7α, 12α-Trihydroxycoprostan-24-One Apparently Derived from 3α, 7α, 12α-Trihydroxy-24-Oxocoprostanoic Acid, A Postulated Intermediate of Bile Acid Biosynthesis. / Yuri, Masatoshi; Tokumoto, Marie; Hara, Noriyuki その他.
In: Chemical and Pharmaceutical Bulletin, Vol. 41, No. 7, 01.01.1993, p. 1327-1329.

研究成果: Article › 査読

Yuri, M, Tokumoto, M, Hara, N, Fujimoto, Y, Kobayashi, N & Morisaki, M 1993, 'Identification of 27-Nor-3a, 7α, 12α-Trihydroxycoprostan-24-One Apparently Derived from 3α, 7α, 12α-Trihydroxy-24-Oxocoprostanoic Acid, A Postulated Intermediate of Bile Acid Biosynthesis', Chemical and Pharmaceutical Bulletin, vol. 41, no. 7, pp. 1327-1329. https://doi.org/10.1248/cpb.41.1327

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title = "Identification of 27-Nor-3a, 7α, 12α-Trihydroxycoprostan-24-One Apparently Derived from 3α, 7α, 12α-Trihydroxy-24-Oxocoprostanoic Acid, A Postulated Intermediate of Bile Acid Biosynthesis",

abstract = "Incubation of [27-13C]-3a,7a,12a-trihydroxycoprost-24-en-26-oic acid with rat liver homogenate followed by l3C-NMR analysis of the incubation product has resulted in the identification of [26-13C]-27-nor-3a,7a,12a-trihydroxycoprostan-24-one, supporting the idea that the substrate has been metabolized into 3a,7a,12a-trihydroxy-24-oxocoprostan-26-oic acid CoA derivative.",

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